Document Detail

The feasibility of left ventricular mechanical support as a bridge to cardiac recovery.
MedLine Citation:
PMID:  17257894     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the achievability of device weaning in patients receiving left ventricular assist devices (LVADs) as a bridge to transplantation.
METHODS: Eighteen consecutive patients receiving a LVAD between September 1997 and June 2002 were included in the study. During a four-month follow-up, patients were repeatedly evaluated with right heart catheterization and echocardiography and, if functional improvement was observed, studied with the device turned off. Cardiac recovery was defined as off-pump LVEF>or=40% together with a significant improvement in invasive haemodynamic measurements (CI>or=2.5 and PCWP<or=10-12 mm Hg). Patients fulfilling these criteria were considered for weaning.
RESULTS: Three patients fulfilled the predefined criteria for cardiac recovery and were subjected to device explantation. In one patient, a young female with acute myocarditis, the following course was uneventful. In the second patient, a male with dilated cardiomyopathy, heart failure reoccurred only a few days later. The third patient had a relapse of giant cell myocarditis and was transplanted. One patient underwent transplantation before follow-up evaluation could be performed.
CONCLUSION: In our experience, patients with severe advanced heart failure are unlikely to show significant cardiac recovery following treatment with LVAD, in contrast to previous suggestions.
Hans Liden; Kristjan Karason; Claes-Håkan Bergh; Folke Nilsson; Bansi Koul; Lars Wiklund
Related Documents :
22048994 - Clinical and electrophysiological characteristics in patients with sustained monomorphi...
6318524 - Echocardiographic features in familial amyloidosis with polyneuropathy.
448784 - Affairs of the wounded heart: penetrating cardiac wounds.
1615794 - Significance of aborted cardiac arrest and sustained ventricular tachycardia in patient...
3165614 - Relation between serum levels of tissue polypeptide antigen (tpa) and cancer antigen 12...
10750364 - Diaschisis and acetazolamide reactivity in brainstem infarction.
Publication Detail:
Type:  Case Reports; Journal Article; Multicenter Study     Date:  2007-01-25
Journal Detail:
Title:  European journal of heart failure     Volume:  9     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-17     Completed Date:  2007-09-20     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  525-30     Citation Subset:  IM    
Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, S-413 45 Gothenburg, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiomyopathy, Dilated / complications,  physiopathology
Cardiomyopathy, Hypertrophic / complications,  physiopathology
Echocardiography, Doppler
Exercise Test
Feasibility Studies
Follow-Up Studies
Heart Catheterization
Heart Failure / etiology,  physiopathology*,  surgery*
Heart Transplantation
Heart-Assist Devices*
Middle Aged
Myocardial Ischemia / complications,  physiopathology
Myocarditis / complications,  physiopathology
Prospective Studies
Recovery of Function*
Stroke Volume
Sweden / epidemiology
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Alpha1-adrenergic stress induces downregulation of Na+/Ca2+ exchanger in myocardial preparations fro...
Next Document:  Molecular mechanisms of cardiomyocyte regeneration and therapeutic outlook.