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The feasibility of an experimental model of donors after cardiac death in remote ischemic preconditioning studies for renal transplantation in porcine.
MedLine Citation:
PMID:  24604310     Owner:  NLM     Status:  Publisher    
PURPOSE: To evaluate the feasibility of an experimental model of donors after cardiac death in remote ischemic preconditioning studies.
METHODS: Twelve Landrace pigs were used as organ donors. They underwent cardiac arrest by coronary en block suture and interruption of ventilatory support. Haemodynamic data regarding the donor surgical protocol were evaluated. Studies variables included mean heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, central venous pressure and oxygen saturation and the time to death.
RESULTS: Haemodynamic parameter indicated that the circulatory failure occurred after nine minutes of en block coronary suture and respiratory support interruption. The circulatory collapse occurred evenly across all groups. The heart rate and central venous pressure were statistically different between groups (p=0.023 and p=0.04), respectively. The remote preconditioning resulted in delayed time of death.
CONCLUSIONS: The model is feasible, and was easily reproduced. The ischemic remote preconditioning tends to a slight increase in circulatory failure time.
João Paulo Figueiredo Camarço; Lucio Kenny Morais; Juan Duque Moreno; Matheus Castrillon Rassi; Mylena Naves de Castro Rocha Camarço; Pedro Figueiredo Guimarães; Claudemiro Quireze
Publication Detail:
Journal Detail:
Title:  Acta cirurgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia     Volume:  29     ISSN:  1678-2674     ISO Abbreviation:  Acta Cir Bras     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-3-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9103983     Medline TA:  Acta Cir Bras     Country:  -    
Other Details:
Languages:  ENG     Pagination:  82-86     Citation Subset:  -    
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