| The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects. | |
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MedLine Citation:
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PMID: 22210925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The precise orosensory inputs engaged for dietary lipids detection in humans are unknown. We evaluated whether a common single nucleotide polymorphism (rs1761667) in the CD36 gene that reduces CD36 expression and the addition of orlistat, a lipase inhibitor, to reduce FA release from triacylglycerols (TGs), the main component of dietary fats, would attenuate fat orosensory sensitivity in humans. Twenty-one obese subjects with different rs1761667 genotypes (6 AA, 7 AG, and 8 GG) were studied on two occasions in which oleic acid and triolein orosensory detection thresholds were measured using emulsions prepared with and without orlistat. Subjects homozygous for the G-allele had 8-fold lower oral detection thresholds for oleic acid and triolein than subjects homozygous for the A allele, which associates with lower CD36 expression (P = 0.03). Thresholds for heterozygous subjects were intermediate. The addition of orlistat increased detection thresholds for triolein (log threshold = -0.3 ± 0.2 vs. 0.3 ± 0.1; P < 0.001) but not oleic acid (log threshold = -1.0 ± 0.2 vs. -0.8 ± 0.2; P > 0.2). In conclusion, this is the first experimental evidence for a role of CD36 in fat gustatory perception in humans. The data also support involvement of lingual lipase and are consistent with the concept that FA and not TG is the sensed stimulus. |
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Authors:
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Marta Yanina Pepino; Latisha Love-Gregory; Samuel Klein; Nada A Abumrad |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-12-31 |
Journal Detail:
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Title: Journal of lipid research Volume: 53 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-29 Completed Date: 2012-06-28 Revised Date: 2013-05-22 |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: United States |
Other Details:
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Languages: eng Pagination: 561-6 Citation Subset: IM |
Affiliation:
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Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USA. ypepino@dom.wustl.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD36 / genetics*, metabolism Dietary Fats / metabolism* Female Food Preferences / physiology Genotype Humans Lipase / genetics* Male Obesity / enzymology*, genetics, metabolism Oleic Acid / metabolism Polymorphism, Single Nucleotide / genetics* Taste / genetics* Triolein / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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DK 37948/DK/NIDDK NIH HHS; DK 56341/DK/NIDDK NIH HHS; DK033301/DK/NIDDK NIH HHS; DK56351/DK/NIDDK NIH HHS; DK60022/DK/NIDDK NIH HHS; KL2 RR024994/RR/NCRR NIH HHS; KL2RR024994/RR/NCRR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD36; 0/Dietary Fats; 112-80-1/Oleic Acid; 122-32-7/Triolein; EC 3.1.1.3/Lipase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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