Document Detail


The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects.
MedLine Citation:
PMID:  22210925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The precise orosensory inputs engaged for dietary lipids detection in humans are unknown. We evaluated whether a common single nucleotide polymorphism (rs1761667) in the CD36 gene that reduces CD36 expression and the addition of orlistat, a lipase inhibitor, to reduce FA release from triacylglycerols (TGs), the main component of dietary fats, would attenuate fat orosensory sensitivity in humans. Twenty-one obese subjects with different rs1761667 genotypes (6 AA, 7 AG, and 8 GG) were studied on two occasions in which oleic acid and triolein orosensory detection thresholds were measured using emulsions prepared with and without orlistat. Subjects homozygous for the G-allele had 8-fold lower oral detection thresholds for oleic acid and triolein than subjects homozygous for the A allele, which associates with lower CD36 expression (P = 0.03). Thresholds for heterozygous subjects were intermediate. The addition of orlistat increased detection thresholds for triolein (log threshold = -0.3 ± 0.2 vs. 0.3 ± 0.1; P < 0.001) but not oleic acid (log threshold = -1.0 ± 0.2 vs. -0.8 ± 0.2; P > 0.2). In conclusion, this is the first experimental evidence for a role of CD36 in fat gustatory perception in humans. The data also support involvement of lingual lipase and are consistent with the concept that FA and not TG is the sensed stimulus.
Authors:
Marta Yanina Pepino; Latisha Love-Gregory; Samuel Klein; Nada A Abumrad
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-12-31
Journal Detail:
Title:  Journal of lipid research     Volume:  53     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-29     Completed Date:  2012-06-28     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  561-6     Citation Subset:  IM    
Affiliation:
Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USA. ypepino@dom.wustl.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD36 / genetics*,  metabolism
Dietary Fats / metabolism*
Female
Food Preferences / physiology
Genotype
Humans
Lipase / genetics*
Male
Obesity / enzymology*,  genetics,  metabolism
Oleic Acid / metabolism
Polymorphism, Single Nucleotide / genetics*
Taste / genetics*
Triolein / metabolism
Grant Support
ID/Acronym/Agency:
DK 37948/DK/NIDDK NIH HHS; DK 56341/DK/NIDDK NIH HHS; DK033301/DK/NIDDK NIH HHS; DK56351/DK/NIDDK NIH HHS; DK60022/DK/NIDDK NIH HHS; KL2 RR024994/RR/NCRR NIH HHS; KL2RR024994/RR/NCRR NIH HHS; R01 DK060022/DK/NIDDK NIH HHS; UL1 RR024992/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD36; 0/Dietary Fats; 112-80-1/Oleic Acid; 122-32-7/Triolein; EC 3.1.1.3/Lipase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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