Document Detail


The fatty acid elongase NOA is necessary for viability and has a somatic role in Drosophila sperm development.
MedLine Citation:
PMID:  17666430     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The essential gene noa (CG 3971; also known as Baldspot) encodes a very long chain fatty acid elongase which is most similar to the mammalian elongase ELOVL6. noa is expressed in the nervous system from embryogenesis on, in imaginal discs, the fat body, malpighian tubules and in the gonads of both sexes. Its function is dose dependent, since reduced levels of noa RNA lead to impaired motility and severely reduced viability. In testes, noa RNA is detected in the cyst cells during the postmeiotic phase of germ cell development. An RNAi construct selectively driven in cyst cells leads to male sterility, demonstrating the necessity of noa function for male germline development and the interaction of the somatic cyst cells with the developing sperm.
Authors:
Anita Jung; Martin Hollmann; Mireille A Schäfer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-31
Journal Detail:
Title:  Journal of cell science     Volume:  120     ISSN:  0021-9533     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-10     Completed Date:  2007-11-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2924-34     Citation Subset:  IM    
Affiliation:
FB18 Zoologie/Entwicklungsbiologie, Universität Kassel, Heinrich-Plett-Str. 40, 34132 Kassel, Germany.
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MeSH Terms
Descriptor/Qualifier:
3' Untranslated Regions / metabolism
5' Untranslated Regions / metabolism
Acetyltransferases / chemistry,  genetics,  metabolism*
Amino Acid Sequence
Animals
Cell Communication
Cell Survival
DNA Transposable Elements / genetics
Drosophila melanogaster / cytology,  embryology,  enzymology*,  genetics
Embryo, Nonmammalian / cytology,  enzymology
Enhancer Elements, Genetic / genetics
Gene Expression Profiling
Gene Expression Regulation, Enzymologic
Genes, Insect
Male
Molecular Sequence Data
Mutation / genetics
Organ Specificity
RNA, Messenger / genetics,  metabolism
Sequence Alignment
Spermatogenesis
Spermatozoa / cytology,  enzymology*,  growth & development*
Temperature
Testis / cytology,  enzymology
Chemical
Reg. No./Substance:
0/3' Untranslated Regions; 0/5' Untranslated Regions; 0/DNA Transposable Elements; 0/RNA, Messenger; EC 2.3.1.-/Acetyltransferases; EC 2.3.1.-/fatty acid elongases

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