| The fatty acid desaturation index of blood lipids, as a biomarker of hepatic stearoyl-CoA desaturase expression, is a predictive factor of breast cancer risk. | |
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MedLine Citation:
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PMID: 20935562 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: This review summarizes epidemiological data linking the fatty acid desaturation index measured in blood lipids, as a biomarker of hepatic stearoyl-CoA desaturase activity, the key enzyme involved in the synthesis of monounsaturated fatty acids from saturated fatty acids, to breast cancer risk. The biological plausibility of this association is discussed. RECENT FINDINGS: Epidemiological cohort studies reported an association between a high saturated to monounsaturated fatty acid ratio measured in blood lipids, indicating low stearoyl-CoA desaturase-1 activity, and decreased breast cancer risk. The suppression of stearoyl-CoA desaturase expression reduces cancer cell proliferation and in-vitro invasiveness, and dramatically impairs tumor formation and growth. These effects could not be overcome by supplying exogenous monounsaturated fatty acids. SUMMARY: Epidemiological findings, in accordance with experimental data, suggested that decreased hepatic stearoyl-CoA desaturase expression/activity may be related to decreased risk of breast cancer. |
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Authors:
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Véronique Chajès; Virginie Joulin; Françoise Clavel-Chapelon |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in lipidology Volume: 22 ISSN: 1473-6535 ISO Abbreviation: Curr. Opin. Lipidol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010000 Medline TA: Curr Opin Lipidol Country: England |
Other Details:
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Languages: eng Pagination: 6-10 Citation Subset: IM |
Affiliation:
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Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France. chajesv@visitors.iarc.fr |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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