| The fatty acid composition of human gliomas differs from that found in nonmalignant brain tissue. | |
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MedLine Citation:
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PMID: 8972462 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To compare the fatty acid composition of tumor tissue from glioma patients with that of normal brain tissue, tissue samples were obtained from 13 glioma patients and from 3 nonmalignant patients. Following lipid extraction, total fatty acid composition was measured using gas-liquid chromatography. samples were further separated into phospholipids and neutral lipids. Representative samples were then separated into phospholipid classes by thin-layer chromatography and the fatty acid composition assayed. Levels of the polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA), were significantly reduced (P = 0.029) in the glioma samples compared with normal brain samples; mean values were 4.8 +/- 2.9% and 9.2 +/- 1.0%, respectively. This reduction in glioma DHA content was also observed in terms of phospholipids (4.6 +/- 2.1% vs. 9.6 +/- 0.8%, P = 0.002). The phosphatidylserine and phosphatidylethanolamine phospholipid classes were reduced in the glioma samples. Differences were also noted in the n-6 PUFA content between glioma and normal brain samples. The glioma content of the n-6 PUFA linoleic acid was significantly greater (P < 0.05) than that observed in the control samples in terms of total lipids. Thus, the fatty acid composition of human gliomas differs from that found in nonmalignant brain tissue. |
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Authors:
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D D Martin; M E Robbins; A A Spector; B C Wen; D H Hussey |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lipids Volume: 31 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-04-01 Completed Date: 1997-04-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1283-8 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City 52242, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Brain Chemistry* Brain Neoplasms / chemistry*, diet therapy, therapy Child Child, Preschool Dietary Fats, Unsaturated / therapeutic use Docosahexaenoic Acids / analysis Fatty Acids / analysis* Fatty Acids, Unsaturated / analysis, therapeutic use Female Glioma / chemistry*, diet therapy, therapy Humans Lipids / analysis Male Middle Aged Phospholipids / analysis |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats, Unsaturated; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Lipids; 0/Phospholipids; 25167-62-8/Docosahexaenoic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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