Document Detail

The fate of trans-caftaric acid administered into the rat stomach.
MedLine Citation:
PMID:  17300159     Owner:  NLM     Status:  MEDLINE    
trans-Caftaric acid is the most abundant nonflavonoid phenolic compound in grapes and wines. It occurs in chicory and is one of the bioactive components of Echinacea purpurea. In order to fill the gap of knowledge about its bioavailability in mammals, we investigated its absorption, tissue distribution, and metabolism in rats. Assuming that the stomach is a relevant site of absorption of dietary polyphenols, a solution of trans-caftaric acid was maintained in the ligated stomach of anaesthetized rats for 20 min. Intact trans-caftaric acid was detected in rat plasma at both 10 and 20 min (293 +/- 45 and 334 +/- 49 ng/mL, respectively), along with its O-methylated derivative trans-fertaric acid, whose concentration rose over time (from 92 +/- 12 to 185 +/- 24 ng/mL). At 20 min, both trans-caftaric acid and trans-fertaric acid were detected in the kidney (443 +/- 78 and 2506 +/- 514 ng/g, respectively) but not in the liver. Only trans-fertaric acid was found in the urine (33.3 +/- 12.8 microg/mL). In some rats, trans-caftaric acid was detected in the brain (180 +/- 20 ng/g).
Andreja Vanzo; Roberto Cecotti; Urska Vrhovsek; Adriana M Torres; Fulvio Mattivi; Sabina Passamonti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  55     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-15     Completed Date:  2007-06-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1604-11     Citation Subset:  IM    
Agricultural Institute of Slovenia, Hacquetova 17, 1001 Ljubljana, Slovenia.
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MeSH Terms
Biological Availability
Brain Chemistry
Fruit / chemistry
Kidney / chemistry
Phenols / administration & dosage*,  analysis,  blood,  pharmacokinetics*
Rats, Wistar
Stomach / metabolism*
Tissue Distribution
Vitis / chemistry
Reg. No./Substance:
0/Phenols; 0/caftaric acid; 0/fertaric acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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