| On the fate of ingested Bacillus spores. | |
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MedLine Citation:
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PMID: 10919516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spores of various Bacillus species, including B. subtilis, B. cereus and B. clausii, are used as probiotics, although they are generally absent from the normal microflora of man. We used two nonpathogenic Bacillus species, B. subtilis and B. clausii, to follow the fate of spores inoculated intragastrically in mice. We did not find detectable amounts of vegetative cells in intestinal samples, probably because of high toxicity of the conjugated bile salt taurodeoxycholic acid against Bacillus species. Both spores and cells were detected in the lymph nodes and spleen of one mouse. Our results indicate that Bacillus is present in the intestinal tract solely as spores and that nonpathogenic Bacillus spores may germinate in lymphoid organs, a finding reminiscent of B. anthracis germination in macrophages. These results indicate that any claimed probiotic effect of B. subtilis should be due to spores or, alternatively, to vegetative growth outside the intestine. |
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Authors:
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M R Spinosa; T Braccini; E Ricca; M De Felice; L Morelli; G Pozzi; M R Oggioni |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Research in microbiology Volume: 151 ISSN: 0923-2508 ISO Abbreviation: Res. Microbiol. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-11-08 Completed Date: 2000-11-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8907468 Medline TA: Res Microbiol Country: FRANCE |
Other Details:
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Languages: eng Pagination: 361-8 Citation Subset: IM |
Affiliation:
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Dipartimento di Biologia Molecolare, Università di Siena, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Bacillus / drug effects, physiology* Bacillus subtilis / drug effects, physiology Bile Acids and Salts / pharmacology Deoxycholic Acid / pharmacology Female Intestines / microbiology* Lymph Nodes / microbiology Mice Mice, Inbred BALB C Microbial Sensitivity Tests Probiotics* Spores, Bacterial / drug effects, physiology* Taurodeoxycholic Acid / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 516-50-7/Taurodeoxycholic Acid; 83-44-3/Deoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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