Document Detail

The fate of hypertrophic chondrocytes in growth plates transplanted intramuscularly in the rabbit.
MedLine Citation:
PMID:  3568489     Owner:  NLM     Status:  MEDLINE    
Sixteen implants of fetal growth cartilage of New Zealand white rabbits of both sexes were implanted intramuscularly into an adult animal of the opposite sex. Endochondral ossification was recognized in 11 of the 16 implants. The sex of the osteoblasts and chondrocytes was determined by counting the sex chromatin body in five areas of abundant endochondral ossification. The bone grown adjacent to the implant was predominantly of recipient type in all of the specimens (p less than 0.01). Most of the chondrocytes gradually lost stainability to Feulgen-Schiff stain as they matured, and only a few cells were stained in the calcified zone, indicating the deterioration of nuclear DNA. Thus, the majority of the growth plate chondrocytes are considered to die and be replaced by osteoblasts of a different origin.
T Miki; T Yamamuro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  -     ISSN:  0009-921X     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-06-02     Completed Date:  1987-06-02     Revised Date:  2005-03-03    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  276-82     Citation Subset:  AIM; IM    
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MeSH Terms
Growth Plate / pathology,  transplantation*
Hypertrophy / pathology
Osteoblasts / cytology
Sex Characteristics
Sex Chromatin / ultrastructure
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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