| The fate of drotaverine-acephyllinate in rat and man. I. Absorption, distribution and excretion in the rat. | |
| | |
MedLine Citation:
|
PMID: 6714267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Two different labelled forms were used for the pharmacokinetic investigations: the carbon 1 in the isoquinoline ring (Drotaverine-14C-Acephyllinate) and the carboxyl group of theophylline-7-acetic acid (Drotaverine-Acephylline-14C-ate). Drotaverine-14C-Acephyllinate was rapidly absorbed from duodenal and ileal segments. Biliary excretion was substantial after oral administration and radioactivity was excreted mostly in the feces. Absorption of Drotavenine-Acephylline-14-C-ate from the gastrointestinal tract was very poor and radioactivity was therefore excreted for the most part in the feces. The results of the study were confirmed by whole body autoradiography. |
| | |
Authors:
|
I Szatmári; G Simon; Z Vargay; E Tóth; T Szüts |
Related Documents
:
|
8149847 - Long-term observations on morphological changes of choledochal epithelium after choledo... 7234017 - The effect of portocaval shunt on bile flow and maximal biliary excretion of bromsulfop... 3710437 - Effect of combined treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and phototherapy ... 5972167 - The effects of urea and hydrochlorothiazide on the renal functions of rat and domestic ... 6709117 - Effect of experimentally induced renal failure upon the fertility in rats. fertility in... 3767367 - Development of vitamin d3 25-hydroxylase activity in rat liver microsomes. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: European journal of drug metabolism and pharmacokinetics Volume: 9 ISSN: 0378-7966 ISO Abbreviation: Eur J Drug Metab Pharmacokinet Publication Date: 1984 Jan-Mar |
Date Detail:
|
Created Date: 1984-06-20 Completed Date: 1984-06-20 Revised Date: 2011-02-02 |
Medline Journal Info:
|
Nlm Unique ID: 7608491 Medline TA: Eur J Drug Metab Pharmacokinet Country: FRANCE |
Other Details:
|
Languages: eng Pagination: 11-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Autoradiography Breath Tests Drug Combinations / metabolism, urine Duodenum / metabolism Feces / analysis Ileum / metabolism Intestinal Absorption Male Papaverine / analogs & derivatives*, metabolism, urine Rats Theophylline / analogs & derivatives*, metabolism, urine Tissue Distribution |
| Chemical | |
Reg. No./Substance:
|
0/Drug Combinations; 58-55-9/Theophylline; 58-74-2/Papaverine; 61954-97-0/drotaverine, acephyllinate drug combination |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Absorption, metabolism and excretion of 14C-sultopride in the rat.
Next Document: Comparative pharmacokinetics of 14C-piperacillin following intravenous and intraperitoneal administr...