Document Detail

The fate of drotaverine-acephyllinate in rat and man. I. Absorption, distribution and excretion in the rat.
MedLine Citation:
PMID:  6714267     Owner:  NLM     Status:  MEDLINE    
Two different labelled forms were used for the pharmacokinetic investigations: the carbon 1 in the isoquinoline ring (Drotaverine-14C-Acephyllinate) and the carboxyl group of theophylline-7-acetic acid (Drotaverine-Acephylline-14C-ate). Drotaverine-14C-Acephyllinate was rapidly absorbed from duodenal and ileal segments. Biliary excretion was substantial after oral administration and radioactivity was excreted mostly in the feces. Absorption of Drotavenine-Acephylline-14-C-ate from the gastrointestinal tract was very poor and radioactivity was therefore excreted for the most part in the feces. The results of the study were confirmed by whole body autoradiography.
I Szatmári; G Simon; Z Vargay; E Tóth; T Szüts
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of drug metabolism and pharmacokinetics     Volume:  9     ISSN:  0378-7966     ISO Abbreviation:  Eur J Drug Metab Pharmacokinet     Publication Date:    1984 Jan-Mar
Date Detail:
Created Date:  1984-06-20     Completed Date:  1984-06-20     Revised Date:  2011-02-02    
Medline Journal Info:
Nlm Unique ID:  7608491     Medline TA:  Eur J Drug Metab Pharmacokinet     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  IM    
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MeSH Terms
Breath Tests
Drug Combinations / metabolism,  urine
Duodenum / metabolism
Feces / analysis
Ileum / metabolism
Intestinal Absorption
Papaverine / analogs & derivatives*,  metabolism,  urine
Theophylline / analogs & derivatives*,  metabolism,  urine
Tissue Distribution
Reg. No./Substance:
0/Drug Combinations; 58-55-9/Theophylline; 58-74-2/Papaverine; 61954-97-0/drotaverine, acephyllinate drug combination

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