Document Detail

The fate of diethylstilbestrol in the pregnant mouse.
MedLine Citation:
PMID:  819646     Owner:  NLM     Status:  MEDLINE    
There is much current interest in the effect of diethylstilbestrol (DES) on the mammalian fetus; however, little is known concerning the physiologic disposition of DES during pregnancy. Radiolabeled (14C or 3H) DES (30 mug/kg) was given to 16-day pregnant mice and its metabolism, distribution and excretion were studied. After i.v. administration, DES was rapidly cleared from the plasma. The plasma decay rates could be described by the sum of four exponentials having T 1/2 values of 4 seconds, 1.1 minutes, 14 minutes and 13 hours. Moreover, conjugated products of DES accounted for more than one-half of the plasma radioactivity by 5 minutes after dosing. The parent compound was rapidly distributed to blood cells, but the liver was the major site of accumulation of DES and its metabolites. In fact, the total radioactivity in this organ accounted for 50% of the injected dose within 2.5 minutes after treatment. Significant concentrations of radioactivity persisted in liver throughout the 16-hour experiment, with DES conjugates accounting for 80% of the hepatic 14C activity at all time points examined. Approximately 56% of the dose was excreted in the feces within 24 hours, primarily as the parent compound. With DES as substrate, significant levels of UDP-glucuronyltransferase were determined in maternal and fetal liver but not in maternal uterus, placenta of fetal gut. Although the mouse placenta appeared to retard the passage of DES into the fetal compartment, a 3-fold accumulation (relative to fetal plasma) of the compound was found in the fetal reproductive tract.
H C Shah; J A McLachlan
Related Documents :
18979506 - Absorption, metabolism and excretion of choladi green tea flavan-3-ols by humans.
19726456 - Pharmacokinetics of gemcitabine and metabolites in a patient with double-sided nephrect...
8345566 - Effect of gonadal hormones on the plasma clearance and metabolite formation of antipyri...
8910856 - Screening for cytochrome p450 3a in man: studies with midazolam and nifedipine.
2418286 - Catecholamine, renin, aldosterone, and arginine vasopressin responses to lower body neg...
7671136 - Correlation between levels of free and protein-bound plasma porphyrin and urinary porph...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  197     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  687-96     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Proteins / metabolism
Diethylstilbestrol / analysis,  metabolism*,  urine
Feces / analysis
Fetus / metabolism
Glucuronosyltransferase / metabolism
Liver / metabolism
Maternal-Fetal Exchange
Protein Binding
Reg. No./Substance:
0/Blood Proteins; 56-53-1/Diethylstilbestrol; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Iodmetric and spectrophotometric assays for cephradine after its hydrolysis with a beta-lactamase.
Next Document:  Frontal cerebral cortex and photic epilepsy of the baboon Papio papio (author transl)