Document Detail


The fate of Depogen in rats.
MedLine Citation:
PMID:  1023268     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studying the metabolism of Depogen in rats we have worked out a method for the purification, isolation and separation of the drug and its potential metabolites. In the basic fraction we have found the same metabolic pathway of Drotaverin published earlier by us. In the focus of our recent work was the fate of the theophylline-7-acetic acid and its eventual biotransformed products. We have stated that theophylline-7-acetic acid contrasts with the theophylline excresa in unchanged form, which has been confirmed by several methods.
Authors:
P Szentmiklósi; S Marton; L Gyarmati
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Die Pharmazie     Volume:  31     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  1976  
Date Detail:
Created Date:  1977-05-20     Completed Date:  1977-05-20     Revised Date:  2007-01-29    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  880-1     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetic Acids / metabolism,  urine
Animals
Autoradiography
Chromatography, Thin Layer
Female
Male
Mass Spectrometry
Rats
Rats, Inbred Strains
Spectrophotometry, Ultraviolet
Theophylline / metabolism*,  urine
Time Factors
Chemical
Reg. No./Substance:
0/Acetic Acids; 58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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