| A fatal dichlorvos poisoning: concentrations in biological specimens. | |
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MedLine Citation:
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PMID: 18547356 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 54-year-old man was found dead with a bottle containing a brownish fluid near him. A toxicological screening was carried out in blood, urine, and stomach content. Only dichlorvos (2,2 dichlorovinyl O-O dimethylphosphate or DDVP) was found. A simple and rapid method, using DDVP-D(6) as an internal standard, was developed for the determination of DDVP by gas chromatography/mass spectrometry (GC/MS). The method was linear from 1 to 10 mg/L. Intraday and interday precisions were all <15%. DDVP concentration in cardiac blood was approximately four times higher than in peripheral blood. A high concentration was found in the heart showing a cardiac tropism of DDVP, kidney and lung concentrations being much lower. No DDVP was found in liver. DDVP stomach content was 38 g. The amount presumed ingested was 82 g, c. 1000 mg/kg of body. The oral LD(50) for DDVP ranges between 20 and 1090 mg/kg in animals but is not known for humans. |
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Authors:
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Emuri Abe; Charlotte Duverneuil; Geoffroy de la Grandmaison; Jean-Claude Alvarez |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of forensic sciences Volume: 53 ISSN: 1556-4029 ISO Abbreviation: J. Forensic Sci. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-21 Completed Date: 2008-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375370 Medline TA: J Forensic Sci Country: United States |
Other Details:
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Languages: eng Pagination: 997-1000 Citation Subset: IM |
Affiliation:
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Laboratoire de Pharmacologie-Toxicologie, Centre Hospitalier Universitaire Raymond Poincaré, AP-HP, et Université Versailles Saint Quentin, 104 Boulevard Raymond. Poincaré, 92380 Garches, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dichlorvos
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analysis*,
poisoning* Forensic Toxicology Gas Chromatography-Mass Spectrometry Gastrointestinal Contents / chemistry Humans Insecticides / analysis*, poisoning* Kidney / chemistry Lung / chemistry Male Middle Aged Molecular Structure Myocardium / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Insecticides; 62-73-7/Dichlorvos |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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