| A fatal case of oleandrin poisoning. | |
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MedLine Citation:
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PMID: 18602779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The study presents a case of fatal poisoning with oleander leaves in an adult diabetic male. After repeated vomiting, and gastrointestinal distress the patient was admitted at the hospital with cardiac symptoms 1h after the ingestion. Urine samples were assayed immunochemically and by GC-MS for drugs of abuse and for general toxicological screen. Blood was analyzed for alcohol and volatiles by static head space GC-MS. Blood and oleander leaves were analyzed by LC-MS/MS for oleandrin and related compounds, the main cardiac glycosides of Nerium oleander. Oleandrin was detected by LC-MS/MS in the blood sample at a concentration of approximately 10 ng/ml. Another cardiac glycoside with pseudo-molecular ion of m/z 577, a likely structural isomer of oleandrin, was also detected in the blood and oleander leaves. However, by using the response as a function of concentration for oleandrin, this cardiac glycoside was roughly estimated at a concentration of approximately 10 ng/ml in the deceased blood. This would give a total fatal blood concentration of cardiac glycosides of about approximately 20 ng/ml in the deceased blood. |
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Authors:
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Ibrahim A Wasfi; Omar Zorob; Nawal A Al katheeri; Anwar M Al Awadhi |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2008-07-07 |
Journal Detail:
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Title: Forensic science international Volume: 179 ISSN: 1872-6283 ISO Abbreviation: Forensic Sci. Int. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-29 Completed Date: 2008-10-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902034 Medline TA: Forensic Sci Int Country: Ireland |
Other Details:
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Languages: eng Pagination: e31-6 Citation Subset: IM |
Affiliation:
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Department of Forensic Evidence, Forensic Science Laboratory, Abu Dhabi, PO Box 253, United Arab Emirates. iawasfi@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardenolides
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blood,
poisoning* Diabetes Mellitus / drug therapy Forensic Toxicology Gas Chromatography-Mass Spectrometry Heart Arrest / chemically induced Heart Block / chemically induced Humans Male Middle Aged Multiple Organ Failure / chemically induced Phytotherapy / adverse effects* Plant Leaves / poisoning Ventricular Fibrillation / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Cardenolides; 465-16-7/oleandrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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