Document Detail


A fatal case of congenital disseminated Langerhans cell histiocytosis.
MedLine Citation:
PMID:  10503186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The case of a newborn male infant with congenital Langerhans cell histiocytosis (LCH) is presented. At birth, showed cutaneous lesions (papules and vesicles with a haemorrhagic aspect), mucosal and ganglionic involvement. Biopsy of these lesions led to the diagnosis of LCH. At 24 hours of life the patient began with respiratory, hepatic, hematological and renal dysfunction, and died at 72 hours of life, despite corticoid treatment. LHC with vesicles and a rapid and fatal development, has previously only been described in three patients. The differential diagnosis of a disseminated and hemorrhagic vesicular eruption in a newborn infant is extensive and must include LHC.
Authors:
C Goñi-Orayen; R Ruiz-Cano; A Pérez-Martínez; E Escario-Travesedo; M Atienzar-Tobarra; A Martínez-Gutiérrez
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  27     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1999  
Date Detail:
Created Date:  1999-11-05     Completed Date:  1999-11-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  228-30     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Albacete General Hospital, Spain.
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MeSH Terms
Descriptor/Qualifier:
Fatal Outcome
Histiocytes / pathology
Histiocytosis, Langerhans-Cell / congenital*,  drug therapy,  pathology
Humans
Infant, Newborn
Male
Prednisolone / therapeutic use
Chemical
Reg. No./Substance:
50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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