Document Detail


The fat mass and obesity-associated (FTO) gene is associated with intramuscular fat content and growth rate in the pig.
MedLine Citation:
PMID:  19370455     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The association of the FTO gene with obesity has been implicated in various human populations. The FTO gene is also most likely involved in the regulation of energy balance and feed intake. Here, the FTO gene was studied as a candidate gene for fatness and growth rate traits in pigs. The amino acid sequence of the FTO gene showed high conservation among human, pig, and other important domestic animals. Twelve variants including ten SNPs and two indels were detected, and then five SNPs within different genomic regions were genotyped in the ISU Berkshire x Yorkshire pig resource family. The linkage disequilibrium analyses revealed that most of these FTO variants were not in strong LD with each other. The SNPs c.46-139A > T within intron 1 and a synonymous mutation c.594C > G (Ala198Ala) within exon 3 had significant (P < 0.01) associations with average daily gain on test and total lipid percentage in muscle, respectively. Five major haplotypes were identified and the subsequent association analyses suggested that haplotype 2 (-CTTGG-) was the most favorable for increased growth rate, while haplotype 1 (-CTACG-) was unfavorably associated with intramuscular fatness traits.
Authors:
Bin Fan; Zhi-Qiang Du; Max F Rothschild
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Animal biotechnology     Volume:  20     ISSN:  1532-2378     ISO Abbreviation:  Anim. Biotechnol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-16     Completed Date:  2009-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011409     Medline TA:  Anim Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-70     Citation Subset:  IM    
Affiliation:
Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / anatomy & histology*
Amino Acid Sequence
Animals
Base Sequence
Breeding
DNA Primers / genetics
Databases, Genetic
Female
Haplotypes
Humans
Linkage Disequilibrium
Male
Molecular Sequence Data
Obesity / genetics,  pathology,  veterinary
Polymorphism, Single Nucleotide
Proteins / genetics
Sequence Homology, Amino Acid
Species Specificity
Sus scrofa / anatomy & histology*,  classification,  genetics*,  growth & development
Swine Diseases / genetics,  pathology
Chemical
Reg. No./Substance:
0/DNA Primers; 0/FTO protein, human; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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