Document Detail

The fat mass and obesity-associated (FTO) gene is associated with intramuscular fat content and growth rate in the pig.
MedLine Citation:
PMID:  19370455     Owner:  NLM     Status:  MEDLINE    
The association of the FTO gene with obesity has been implicated in various human populations. The FTO gene is also most likely involved in the regulation of energy balance and feed intake. Here, the FTO gene was studied as a candidate gene for fatness and growth rate traits in pigs. The amino acid sequence of the FTO gene showed high conservation among human, pig, and other important domestic animals. Twelve variants including ten SNPs and two indels were detected, and then five SNPs within different genomic regions were genotyped in the ISU Berkshire x Yorkshire pig resource family. The linkage disequilibrium analyses revealed that most of these FTO variants were not in strong LD with each other. The SNPs c.46-139A > T within intron 1 and a synonymous mutation c.594C > G (Ala198Ala) within exon 3 had significant (P < 0.01) associations with average daily gain on test and total lipid percentage in muscle, respectively. Five major haplotypes were identified and the subsequent association analyses suggested that haplotype 2 (-CTTGG-) was the most favorable for increased growth rate, while haplotype 1 (-CTACG-) was unfavorably associated with intramuscular fatness traits.
Bin Fan; Zhi-Qiang Du; Max F Rothschild
Related Documents :
24382125 - Horizontal gene transfer and the rock record: comparative genomics of phylogenetically ...
23313555 - Application of peptide nucleic acid (pna) - pcr clamping technique to investigate the c...
25193495 - Reference genes for expression studies in hypoxia and hyperglycemia models in human umb...
9741465 - Genetic epidemiology study of idiopathic talipes equinovarus.
12505705 - Assessment of cannabinoid induced gene changes: tolerance and neuroprotection.
16339045 - Bovine nalp5, nalp8, and nalp9 genes: assignment to a qtl region and the expression in ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Animal biotechnology     Volume:  20     ISSN:  1532-2378     ISO Abbreviation:  Anim. Biotechnol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-16     Completed Date:  2009-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011409     Medline TA:  Anim Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-70     Citation Subset:  IM    
Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adipose Tissue / anatomy & histology*
Amino Acid Sequence
Base Sequence
DNA Primers / genetics
Databases, Genetic
Linkage Disequilibrium
Molecular Sequence Data
Obesity / genetics,  pathology,  veterinary
Polymorphism, Single Nucleotide
Proteins / genetics
Sequence Homology, Amino Acid
Species Specificity
Sus scrofa / anatomy & histology*,  classification,  genetics*,  growth & development
Swine Diseases / genetics,  pathology
Reg. No./Substance:
0/DNA Primers; 0/FTO protein, human; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Microsatellite analysis characterizes Burkina Faso as a genetic contact zone between Sahelian and Dj...
Next Document:  Associations of a HinfI PCR-RFLP of POU1F1 gene with growth traits in Qinchuan cattle.