| A fast in vitro effect of glucocorticoids on hepatic lipolysis. | |
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MedLine Citation:
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PMID: 1278118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A fast and direct effect of dexamethasone on liver metabolism is reported. In the perfused rat liver, addition of dexamethasone directly to the perfusate is followed by an increase in the level of free fatty acids (FFA) and glycerol. These effects of dexamethasone are evident within 30 minutes of hormone administration. The response to dexamethasone in livers from normal and adrenalectomized rats is similar. While dexamethasone and glucagon both had a lipolytic effect, these effects are not additive. |
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Authors:
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P Divakaran; N Friedmann |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Endocrinology Volume: 98 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 1976 Jun |
Date Detail:
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Created Date: 1976-09-01 Completed Date: 1976-09-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1550-3 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenalectomy Animals Dactinomycin / pharmacology Dexamethasone / pharmacology* Estradiol / pharmacology Fatty Acids, Nonesterified / biosynthesis Glucagon / pharmacology Glucose / metabolism Glycerol / metabolism Lactates / metabolism Lipid Metabolism* Liver / drug effects, metabolism* Male Rats Testosterone / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Lactates; 50-02-2/Dexamethasone; 50-28-2/Estradiol; 50-76-0/Dactinomycin; 50-99-7/Glucose; 56-81-5/Glycerol; 58-22-0/Testosterone; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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