Document Detail

A fast and efficient HPLC-PDA-MS method for detection and identification of pyranochromanone acids in Calophyllum species.
MedLine Citation:
PMID:  23333683     Owner:  NLM     Status:  Publisher    
Pyranochromanone acids isolated from Calophyllum species have shown a variety of biological potentialities including antioxidant, antiulcer, anticancer and anti-Helicobacter pylori activities. These compounds seem to be the main constituents of Cuban Calophyllum species together xanthones and biflavonoids. Recently, the pyranochromanone acids calophyllic acid, isocalophyllic acid, apetalic acid, calolongic acid, isoapetalic acid, pinetoric acid I, pinetoric acid II, were isolated from Calophyllum pinetorum, a Cuban endemic species. The objective of the present work was the development of a rapid and efficient HPLC-DAD-MS method for fast screening of pyranochromanones in the leaves and resins of different endemic Calophyllum spp of Cuba, without clean-up procedures. For this purpose, a generalized fragmentation pathway was proposed and used to characterize, by HPLC-DAD-MS, the pyranochromanone acids in leaves and resins of different Calophyllum species. The developed method enables to detect also minor compounds in Calophyllum spp. The structures proposed by MS data for these compounds were unambiguous confirmed by 1D and 2D-NMR analysis and three new pyranochromanone acids, isocalolongic acid, pinetoric acid III and isopinetoric acid III, were reported here for the first time.
Anna Lisa Piccinelli; Ahmad Oubada Kabani; Cinzia Lotti; Adonis Bello Alarcon; Osmany Cuesta-Rubio; Luca Rastrelli
Related Documents :
489723 - Assimilation of protocatechuic acid and p-hydroxybenzoic acid as an aid to laboratory i...
25486243 - Structures of some novel α-glucosyl diterpene glycosides from the glycosylation of ste...
8002893 - Tuberculosis in farmed rheas (rhea americana).
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-29
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  76C     ISSN:  1873-264X     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  -    
Other Details:
Languages:  ENG     Pagination:  157-163     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Simultaneous quantification and validation of caffeoylquinic acids and flavonoids in Hemistepta lyra...
Next Document:  The stability of amitriptyline N-oxide and clozapine N-oxide on treated and untreated dry blood spot...