| The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Hopkins OCD family study. | |
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MedLine Citation:
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PMID: 11690590 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Obsessive-compulsive disorder (OCD) and tic disorders have phenomenological and familial-genetic overlaps. An OCD family study sample that excludes Tourette's syndrome in probands is used to examine whether tic disorders are part of the familial phenotype of OCD. METHODS: Eighty case and 73 control probands and their first-degree relatives were examined by experienced clinicians using the Schedule for Affective Disorders and Schizophrenia-Lifetime Anxiety version. DSM-IV psychiatric diagnoses were ascertained by a best-estimate consensus procedure. The prevalence and severity of tic disorders, age-at-onset of OCD symptoms, and transmission of OCD and tic disorders by characteristics and type of proband (OCD + tic disorder, OCD - tic disorder) were examined in relatives. RESULTS: Case probands and case relatives had a greater lifetime prevalence of tic disorders compared to control subjects. Tic disorders spanning a wide severity range were seen in case relatives; only mild severity was seen in control relatives. Younger age-at-onset of OCD symptoms and possibly male gender in case probands were associated with increased tic disorders in relatives. Although relatives of OCD + tic disorder and OCD - tic disorder probands had similar prevalences of tic disorders, this result is not conclusive. CONCLUSIONS: Tic disorders constitute an alternate expression of the familial OCD phenotype. |
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Authors:
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M A Grados; M A Riddle; J F Samuels; K Y Liang; R Hoehn-Saric; O J Bienvenu; J T Walkup; D Song; G Nestadt |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biological psychiatry Volume: 50 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-11-05 Completed Date: 2001-12-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 559-65 Citation Subset: IM |
Affiliation:
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Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Case-Control Studies Child Child, Preschool Female Gene Frequency / genetics Genetic Predisposition to Disease / genetics Humans Male Obsessive-Compulsive Disorder / diagnosis, genetics* Phenotype* Tic Disorders / diagnosis, genetics* Tourette Syndrome / diagnosis, genetics |
| Grant Support | |
ID/Acronym/Agency:
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R01 MH50214/MH/NIMH NIH HHS; RR00052/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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