| A familial case of LEOPARD syndrome associated with a high-functioning autism spectrum disorder. | |
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MedLine Citation:
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PMID: 21093184 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A connection between LEOPARD syndrome (a rare autosomal dominant disorder) and autism spectrum disorders (ASDs) may exist. Of four related individuals (father and three sons) with LEOPARD syndrome, all patients exhibited clinical symptoms consistent with ASDs. Findings included aggressive behavior and impairment of social interaction, communication, and range of interests. The coexistence of LEOPARD syndrome and ASDs in the related individuals may be an incidental familial event or indicative that ASDs is associated with LEOPARD syndrome. There have been no other independent reports of the association of LEOPARD syndrome and ASDs. Molecular and biochemical mechanisms that may suggest a connection between LEOPARD syndrome and ASDs are discussed. |
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Authors:
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Yoriko Watanabe; Shoji Yano; Tetsuya Niihori; Yoko Aoki; Yoichi Matsubara; Makoto Yoshino; Toyojiro Matsuishi |
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Publication Detail:
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Type: Journal Article Date: 2010-11-18 |
Journal Detail:
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Title: Brain & development Volume: 33 ISSN: 1872-7131 ISO Abbreviation: Brain Dev. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909235 Medline TA: Brain Dev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 576-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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