Document Detail

Is a failure to recognize an increase in food intake a key to understanding insulin-induced weight gain?
MedLine Citation:
PMID:  18086874     Owner:  NLM     Status:  MEDLINE    
The present study aimed to assess the contribution of energy intake to positive energy balance and weight gain with insulin therapy. Changes in energy intake (self-report and weighed food intake), dietary behavior (auto-questionnaires), resting energy expenditure (REE) (indirect calorimetry), physical activity (accelerometry), and glucosuria were monitored over the first 6 months of insulin therapy in 46 diabetic adults. No change in REE, activity, or glucosuria could explain weight gain in the type 1 (4.1 +/- 0.6 kg, P < 0.0001) or type 2 (1.8 +/- 0.8 kg, P = 0.02) diabetic groups. An increase in energy intake provides the most likely explanation for weight gain with insulin. However, it is not being recognized because of significant underestimation of self-reported food intake, which appears to be associated with increased dietary restraint.
Miriam Ryan; M Barbara E Livingstone; Pierre-Henri Ducluzeau; Agnès Sallé; Manon Genaitay; Patrick Ritz
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Publication Detail:
Type:  Journal Article     Date:  2007-12-17
Journal Detail:
Title:  Diabetes care     Volume:  31     ISSN:  1935-5548     ISO Abbreviation:  Diabetes Care     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-29     Completed Date:  2008-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  448-50     Citation Subset:  IM    
Department of Diabetes and Nutrition, CHU Angers F-49033, France.
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MeSH Terms
Diabetes Mellitus / drug therapy,  physiopathology*
Diabetes Mellitus, Type 1 / drug therapy,  physiopathology
Diabetes Mellitus, Type 2 / drug therapy,  physiopathology
Diet Records
Eating / drug effects*
Energy Intake / drug effects
Energy Metabolism / drug effects
Hypoglycemic Agents / adverse effects,  therapeutic use
Insulin / adverse effects,  therapeutic use*
Middle Aged
Weight Gain / drug effects*
Reg. No./Substance:
0/Hypoglycemic Agents; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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