Document Detail


The failure of long-term feeding of raw soy flour, in the presence or absence of azaserine, to induce carcinogenic changes in the mouse pancreas.
MedLine Citation:
PMID:  3703687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of feeding mice raw or heated soy flours or casein in the presence and absence of injected azaserine were investigated over a period of 18 months. Although the feeding of raw soy flour (compared with heated soy flour or casein) caused a significant inhibition of growth and an enlargement of the pancreas, there was no macroscopic evidence of pancreatic nodules in any of the six experimental groups. Microscopic examination of the pancreas revealed a somewhat higher (not significant) incidence of atypical acinar cell nodules in all animals injected with azaserine, but this difference was little influenced by the diets themselves. We concluded that raw soy flour itself has no carcinogenic effect on the mouse pancreas and does not enhance the sensitivity of the mouse pancreas to azaserine. Thus, it cannot be assumed that the appearance of pancreatic nodules constitutes an obligatory sequela of pancreatic hypertrophy and/or hyperplasia in all species of animals.
Authors:
A Hasdai; I E Liener
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Nutrition and cancer     Volume:  8     ISSN:  0163-5581     ISO Abbreviation:  Nutr Cancer     Publication Date:  1986  
Date Detail:
Created Date:  1986-06-03     Completed Date:  1986-06-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  85-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Azaserine / toxicity*
Body Weight / drug effects
Diet*
Eating / drug effects
Flour / toxicity*
Hot Temperature
Mice
Organ Size / drug effects
Pancreas / drug effects
Pancreatic Neoplasms / chemically induced*
Soybeans*
Time Factors
Chemical
Reg. No./Substance:
115-02-6/Azaserine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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