Document Detail


Is the failing heart energy starved? On using chemical energy to support cardiac function.
MedLine Citation:
PMID:  15271865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The requirement of chemical energy in the form of ATP to support systolic and diastolic work of the heart is absolute. Because of its central role in cardiac metabolism and performance, the subject of this review on energetics in the failing heart is ATP. We briefly review the basics of myocardial ATP metabolism and describe how this changes in the failing heart. We present an analysis of what is now known about the causes and consequences of these energetic changes and conclude by commenting on unsolved problems and opportunities for future basic and clinical research.
Authors:
Joanne S Ingwall; Robert G Weiss
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Circulation research     Volume:  95     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-23     Completed Date:  2005-02-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  135-45     Citation Subset:  IM    
Affiliation:
Brigham and Women's Hospital, Harvard Medical School, Boston, Mass, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism*
Adenylate Kinase / metabolism
Animals
Cardiomyopathy, Hypertrophic, Familial / metabolism
Creatine Kinase / metabolism
Diastole
Energy Metabolism*
Forecasting
Heart Failure / metabolism*
Humans
Hypertrophy, Left Ventricular / metabolism
Isoenzymes / metabolism
Mice
Mitochondria, Heart / metabolism
Myocardial Ischemia / metabolism
Phosphocreatine / metabolism
Stress, Physiological / metabolism
Grant Support
ID/Acronym/Agency:
HL52320/HL/NHLBI NIH HHS; HL56882/HL/NHLBI NIH HHS; HL61912/HL/NHLBI NIH HHS; HL63030/HL/NHLBI NIH HHS; HL63985/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Isoenzymes; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine; EC 2.7.3.2/Creatine Kinase; EC 2.7.4.3/Adenylate Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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