| Is faecal-immunochemical test useful in patients with iron deficiency anaemia and without overt bleeding? | |
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MedLine Citation:
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PMID: 21900058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Both upper and lower endoscopies are indicated in patients with iron deficiency anaemia. However, these examinations are negative in a high proportion of cases. AIMS: To assess whether faecal-immunochemical test (FIT) may be useful in selecting patients at higher risk of bleeding lesions in iron deficiency anaemia patients. METHODS: Iron deficiency anaemia patients without overt bleeding were prospectively enrolled. All patients performed FIT, and underwent both upper and lower endoscopy. Predictive factors of potential bleeding lesions were evaluated at multivariate analysis. RESULTS: FIT was positive in 48 (34.3%) out of 140 enrolled patients, and a potential bleeding lesion was present in 63 (45%) patients. An endoscopic lesion was detected more frequently in FIT-positive than -negative patients (79.2% vs 27.2%; p<0.0001), at both upper endoscopy (52.1% vs 18.5%; p=0.0002) and colonoscopy (33.3% vs 8.7%; p=0.001). At multivariate analysis, FIT was found to be an independent predictor of both bleeding lesions (OR=9.5; 95% CI: 4.1-22; p<0.001) and cancer (OR=4.0, CI: 1.1-15; p=0.029). CONCLUSIONS: FIT positive-iron deficiency anaemia patients without overt bleeding are at increased risk to present with a bleeding lesion at endoscopy, including cancer. FIT positivity in this setting could be useful to prioritize urgent endoscopy. |
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Authors:
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Antonio Cilona; Angelo Zullo; Cesare Hassan; Lorenzo Ridola; Mauro Annese |
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Publication Detail:
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Type: Journal Article Date: 2011-09-06 |
Journal Detail:
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Title: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Volume: 43 ISSN: 1878-3562 ISO Abbreviation: Dig Liver Dis Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-04 Completed Date: 2012-03-29 Revised Date: 2012-07-16 |
Medline Journal Info:
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Nlm Unique ID: 100958385 Medline TA: Dig Liver Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1022-4 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Internal Medicine, Hospital Giovanni Paolo II, Policoro (MT), Italy. antoniocilona@virgilio.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anemia, Iron-Deficiency / complications* Capsule Endoscopy Endoscopy, Gastrointestinal* Female Gastrointestinal Hemorrhage / complications*, diagnosis* Humans Male Middle Aged Multivariate Analysis Occult Blood* |
| Comments/Corrections | |
Comment In:
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Dig Liver Dis. 2012 Jul;44(7):625
[PMID:
22398253
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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