Document Detail


A facile method for the synthesis of N-(α-aminoacyl) sulfonamides.
MedLine Citation:
PMID:  22622015     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
N-Acylsulfonamide derivatives have important applications in organic synthesis and drug discovery. It was found that many problems occurred preparing amino acid derived N-acylsulfonamides with the commonly used coupling approach in our previous studies. In this paper, we report an efficient approach to synthesize various amino acids derived N-acylsulfonamides in high yields without any racemization.
Authors:
S L Wu; M L Chen; Y T Wang; X B Hou; X Y Yang; L Su; H Fang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug discoveries & therapeutics     Volume:  6     ISSN:  1881-7831     ISO Abbreviation:  Drug Discov Ther     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-05-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101493809     Medline TA:  Drug Discov Ther     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  62-8     Citation Subset:  IM    
Affiliation:
School of Pharmacy, Shandong University, Ji'nan, Shandong, China.
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