| The fabrication of low-impedance nanoporous gold multiple-electrode arrays for neural electrophysiology studies. | |
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MedLine Citation:
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PMID: 20203356 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neural electrodes are essential tools for the study of the nervous system and related diseases. Low electrode impedance is a figure of merit for sensitive detection of neural electrical activity and numerous studies have aimed to reduce impedance. Unfortunately, most of these efforts have been tethered by a combination of poor functional coating adhesion, complicated fabrication techniques, and poor fabrication repeatability. We address these issues with a facile method for reliably producing multiple-electrode arrays with low impedance by patterning highly adherent nanoporous gold films using conventional microfabrication techniques. The high surface area-to-volume ratio of self-assembled nanoporous gold results in a more than 25-fold improvement in the electrode-electrolyte impedance, where at 1 kHz, 850 kOmega impedance for conventional Au electrodes is reduced to 30 kOmega for nanoporous gold electrodes. Low impedance provides a superior signal-to-noise ratio for detection of neural activity in noisy environments. We systematically studied the effect of film morphology on electrode impedance and successfully recorded field potentials from rat hippocampal slices. Here, we present our fabrication approach, the relationship between film morphology and impedance, and field potential recordings. |
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Authors:
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Erkin Seker; Yevgeny Berdichevsky; Matthew R Begley; Michael L Reed; Kevin J Staley; Martin L Yarmush |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-03-05 |
Journal Detail:
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Title: Nanotechnology Volume: 21 ISSN: 1361-6528 ISO Abbreviation: Nanotechnology Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-05 Completed Date: 2010-05-18 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101241272 Medline TA: Nanotechnology Country: England |
Other Details:
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Languages: eng Pagination: 125504 Citation Subset: IM |
Affiliation:
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Center for Engineering in Medicine, Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Shriners Hospitals for Children, Boston, MA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Adhesion / physiology Electric Impedance Electrodes* Electrophysiology / instrumentation* Gold / chemistry* Hippocampus / cytology, physiology* Metal Nanoparticles / chemistry* Microscopy, Electron, Scanning Neurons / physiology* Porosity Rats Rats, Sprague-Dawley Silver / chemistry |
| Grant Support | |
ID/Acronym/Agency:
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F32 MH079662-01A1/MH/NIMH NIH HHS; F32-MH079662/MH/NIMH NIH HHS; P41 EB002503-07/EB/NIBIB NIH HHS; P41-EB002503/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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7440-22-4/Silver; 7440-57-5/Gold |
| Comments/Corrections | |
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