Document Detail

fMRI in an oddball task: effects of target-to-target interval.
MedLine Citation:
PMID:  16364059     Owner:  NLM     Status:  MEDLINE    
The amplitude of the P3 event-related potential (ERP) elicited by task-relevant target ("oddball") stimuli has been shown to vary in proportion to the length of time between targets. Here we use functional magnetic resonance imaging (fMRI) to identify neural systems modulated by target interval in a large sample of healthy adults (n=100) during performance of an auditory oddball task that included both target and novel stimuli. A positive relationship was found between target interval and hemodynamic activity in the anterior cingulate and in bilateral lateral prefrontal cortex, temporal-parietal junction, postcentral gryi, thalamus, and cerebellum. This modulation likely represents updating of the working memory template for the target stimuli. There was no such effect of novel interval, suggesting that neuronal modulation may only occur for task-relevant stimuli, possibly in the service of strategic resource allocation processes.
Michael C Stevens; Vince D Calhoun; Kent A Kiehl
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychophysiology     Volume:  42     ISSN:  0048-5772     ISO Abbreviation:  Psychophysiology     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-12-20     Completed Date:  2006-03-07     Revised Date:  2010-04-29    
Medline Journal Info:
Nlm Unique ID:  0142657     Medline TA:  Psychophysiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  636-42     Citation Subset:  IM    
Olin Neuropsychiatry Research Center, The Institute of Living, Hartford, Connecticut 06106, USA.
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MeSH Terms
Brain / physiology
Evoked Potentials / physiology*
Hemodynamics / physiology
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Middle Aged
Psychomotor Performance / physiology
Grant Support
1 K23 MH070036-01/MH/NIMH NIH HHS; 1 R01 EB 000840-01/EB/NIBIB NIH HHS; 1 R01 MH0705539-01/MH/NIMH NIH HHS; 1 R01 MH072681-01/MH/NIMH NIH HHS

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