Document Detail


The eye as metronome of the body.
MedLine Citation:
PMID:  11801266     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vision is much more than just resolving small objects. In fact, the eye sends visual information to the brain that is not consciously perceived. One such pathway entails visual information to the hypothalamus. The retinohypothalamic tract (RHT) mediates light entrainment of circadian rhythms. Retinofugal fibers project to several nuclei of the hypothalamus. These and further projections to the pineal via the sympathetic system provide the anatomical substrate for the neuro-endocrine control of diurnal and longer rhythms. Without the influence of light and dark, many rhythms desynchronize and exhibit free-running periods of approximately 24.2-24.9 hours in humans. This review will demonstrate the mechanism by which the RHT synchronizes circadian rhythms and the importance of preserving light perception in those persons with impending visual loss.
Authors:
Virginia Lubkin; Pouneh Beizai; Alfredo A Sadun
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Survey of ophthalmology     Volume:  47     ISSN:  0039-6257     ISO Abbreviation:  Surv Ophthalmol     Publication Date:    2002 Jan-Feb
Date Detail:
Created Date:  2002-01-21     Completed Date:  2002-03-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0404551     Medline TA:  Surv Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17-26     Citation Subset:  IM    
Affiliation:
New York Eye and Ear Infirmary, New York, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Circadian Rhythm / physiology*
Humans
Hypothalamus / physiology*
Light Signal Transduction / physiology
Nerve Fibers / physiology
Ocular Physiological Phenomena*
Pineal Gland / physiology
Retinaldehyde / physiology*
Sympathetic Nervous System / physiology
Visual Pathways / physiology*
Visual Perception / physiology
Chemical
Reg. No./Substance:
116-31-4/Retinaldehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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