Document Detail


The extrapulmonary effects of inhaled hexoprenaline and salbutamol in healthy individuals.
MedLine Citation:
PMID:  8405027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have investigated the cardiovascular and metabolic effects of multiple inhaled doses of salbutamol and hexoprenaline in 12 healthy volunteers. They inhaled 200 micrograms of salbutamol or hexoprenaline at 15 min intervals for 60 min from a metered dose inhaler (total dose 1000 micrograms). We measured heart rate, blood pressure, total electromechanical systole (as a measure of inotropic response), QTc interval on the ECG, and plasma potassium at baseline, 10 min after each inhalation, and 30 and 60 min after the last inhalation. There was no difference in the effects of the two drugs on blood pressure, total electromechanical systole, or QTc interval. Salbutamol significantly increased heart rate compared with hexoprenaline. Hexoprenaline caused a significantly greater fall in plasma potassium compared with salbutamol.
Authors:
P Bremner; C Burgess; G Purdie; R Beasley; J Crane
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  45     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1993  
Date Detail:
Created Date:  1993-11-04     Completed Date:  1993-11-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  37-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Wellington School of Medicine, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adult
Albuterol / administration & dosage,  pharmacology*
Blood Pressure / drug effects
Female
Heart Rate / drug effects
Hemodynamics / drug effects*
Hexoprenaline / administration & dosage,  pharmacology*
Humans
Male
Potassium / blood*
Chemical
Reg. No./Substance:
18559-94-9/Albuterol; 3215-70-1/Hexoprenaline; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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