Document Detail


The extraction of thallium-201 by the myocardium.
MedLine Citation:
PMID:  872309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concentration of thallium-201 in the myocardium immediately following injection of tracer is the result of both blood flow delivering tracer to the heart and extraction by the myocardium. In these studies, the extraction of thallium-201 by the canine myocardium was determined as a function of heart rate, coronary blood flow, hypoxia, changes in pH, and following administration of propranolol, insulin, and strophanthin. Under basal conditions, extraction fraction measured 88 +/- 2.1%, following pacing to a rate of 195 beats/min extraction fraction remained unchanged at 88.5%. Similar results were found with changes in pH, propranolol, insulin, and strophanthin. Hypoxia caused a significant decrease in extraction fraction to 77.9%. When coronary blood flow was increased in excess of demands by drugs, extraction fraction fell logarithmically.
Authors:
H F Weich; H W Strauss; B Pitt
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  56     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-09-02     Completed Date:  1977-09-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  188-91     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acidosis / metabolism
Alkalosis / metabolism
Animals
Anoxia / metabolism
Coronary Circulation
Dogs
Heart Rate
Insulin / pharmacology
Myocardium / metabolism*
Propranolol / pharmacology
Strophanthins / pharmacology
Thallium / metabolism*
Chemical
Reg. No./Substance:
0/Strophanthins; 11061-68-0/Insulin; 525-66-6/Propranolol; 7440-28-0/Thallium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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