Document Detail

An extract from berries of Aronia melanocarpa modulates the generation of superoxide anion radicals in blood platelets from breast cancer patients.
MedLine Citation:
PMID:  19444773     Owner:  NLM     Status:  In-Process    
Plant antioxidants protect cells against oxidative stress. Because oxidative stress (measured by different biomarkers) is observed in breast cancer patients, the aim of this study was to establish the effects of a polyphenol-rich extract of Aronia melanocarpa (final concentration of 50 microg/mL, 5 min, 37 degrees C) on superoxide anion radicals (O(2)(-*)) and glutathione (GSH) in platelets from patients with breast cancer and in a healthy group in vitro. Generation of O(2)(-*) in platelets before and after incubation with the extract was measured by cytochrome C reduction. Using HPLC, we determined the level of glutathione in blood platelets. We observed a statistically significant increase of biomarkers of oxidative stress such as O(2)(-*) and a decrease in GSH in platelets from patients with breast cancer compared with the healthy group. We showed that the extract from A. melanocarpa added to blood platelets significantly reduced the production of O(2)(-*) in platelets not only from the healthy group but also from patients with breast cancer. Considering the data presented in this study, we have demonstrated the protective role of the extract from A. melanocarpa in patients with breast cancer in vitro.
Magdalena Kedzierska; Beata Olas; Barbara Wachowicz; Anna Stochmal; Wieslaw Oleszek; Arkadiusz Jeziorski; Janusz Piekarski; Rafal Glowacki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-14
Journal Detail:
Title:  Planta medica     Volume:  75     ISSN:  1439-0221     ISO Abbreviation:  Planta Med.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1405-9     Citation Subset:  IM    
Copyright Information:
Georg Thieme Verlag KG Stuttgart-New York.
Department of General Biochemistry, University of Lodz, Lodz, Poland.
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