| An extracellular meiosis-promoting factor in Saccharomyces cerevisiae. | |
| | |
MedLine Citation:
|
PMID: 9639308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Meiosis and sporulation in the yeast Saccharomyces cerevisiae has been classically viewed as an example of unicellular, eukaryotic differentiation that occurs in response to nutritional starvation. We present evidence that S. cerevisiae produces an extracellular factor(s), called meiosis-promoting factor (MEP), that is required, in addition to starvation conditions, for efficient meiosis and sporulation. This factor is secreted and accumulates in a cell density-dependent fashion such that cells at a low density sporulate poorly under conditions in which cells at a high density sporulate efficiently. Conditioned medium from sporulating cells at a high density contains a small anionic molecule that has cytostatic activity and stimulates sporulation of cells at low density under a normal starvation condition. These results indicate that MEP-mediated social communication between cells is required for meiosis and sporulation. |
| | |
Authors:
|
M Hayashi; K Ohkuni; I Yamashita |
Related Documents
:
|
12912978 - Cloning, expression, characterization, and role in autocrine cell growth of cell surfac... 19369908 - Effect of intranasal administration of basic fibroblast growth factor on olfactory epit... 22781398 - Nsc 74859 enhances doxorubicin cytotoxicity via inhibition of epithelial-mesenchymal tr... 1325208 - Diverse receptors for fibroblast growth factors. 12912978 - Cloning, expression, characterization, and role in autocrine cell growth of cell surfac... 20181838 - The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Yeast (Chichester, England) Volume: 14 ISSN: 0749-503X ISO Abbreviation: Yeast Publication Date: 1998 May |
Date Detail:
|
Created Date: 1998-09-15 Completed Date: 1998-09-15 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8607637 Medline TA: Yeast Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 617-22 Citation Subset: IM |
Affiliation:
|
Center for Gene Science, Hiroshima University, Higashi-Hiroshima, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Division Culture Media, Conditioned Gene Expression Regulation, Fungal Growth Substances / biosynthesis*, physiology Meiosis* Plasmids / genetics Saccharomyces cerevisiae / genetics, physiology* Spores, Fungal / genetics, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Culture Media, Conditioned; 0/Growth Substances |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Physical mapping of chromosomes VII and XV of Saccharomyces cerevisiae at 3.5 kb average resolution ...
Next Document: Bicarbonate-mediated social communication stimulates meiosis and sporulation of Saccharomyces cerevi...