Document Detail


An extracellular matrix protein prevents cytokinesis failure and aneuploidy in the C. elegans germline.
MedLine Citation:
PMID:  21558805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interactions between extracellular matrix (ECM) proteins and their transmembrane receptors mediate cytoskeletal reorganization and corresponding changes in cell shape during cell migration, adhesion, differentiation and polarization. Cytokinesis is the final step in cell division as cells employ a contractile ring composed of actin and myosin to partition one cell into two. Cells undergo dramatic changes in cell shape during the division process, creating new membrane and forming an extracellular invagination called the cleavage furrow. However, existing models of cytokinesis include no role for the ECM. In a recent paper, we demonstrate that depletion of a large secreted protein, hemicentin, results in membrane destabilization, cleavage furrow retraction and cytokinesis failure in C. elegans germ cells and in pre-implantation mouse embryos. Here, we demonstrate that cytokinesis failure produces tetraploid intermediate cells with multipolar spindles, providing a potential explanation for the large number of aneuploid progeny observed among C. elegans hemicentin mutant hermaphrodites.
Authors:
Bruce E Vogel; Cynthia Wagner; Joanna Mathis Paterson; Xuehong Xu; Judith L Yanowitz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-06-15
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  10     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-30     Completed Date:  2011-11-02     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1916-20     Citation Subset:  IM    
Affiliation:
Center for Biomedical Engineering and Technology and Department of Physiology, University of Maryland at Baltimore, Baltimore, MD, USA. bvogel@umaryland.edu
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MeSH Terms
Descriptor/Qualifier:
Aneuploidy*
Animals
Caenorhabditis elegans / cytology*
Cytokinesis*
Extracellular Matrix Proteins / physiology*
Germ Cells / cytology*
Germ-Line Mutation
Mice
Tetraploidy
Grant Support
ID/Acronym/Agency:
GM65184/GM/NIGMS NIH HHS; T32HL072751/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Extracellular Matrix Proteins
Comments/Corrections

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