Document Detail


The extracellular matrix, interstitial fluid and ions as a mechanical signal transducer in articular cartilage.
MedLine Citation:
PMID:  10367014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: (1) Provide an overview of the biomechanical factors that are required to analyze and interpret biological data from explant experiments; (2) Present a description of some of the mechano-electrochemical events which occur in cartilage explants during loading. DESIGN: A thorough and provocative discussion on the effects of loading on articular cartilage will be presented. Five simplest loading cases are considered: hydrostatic pressure, osmotic pressure, permeation (pressure loading), confined compression and unconfined compression. Details of how such surface loadings are converted or transduced by the extracellular matrix (ECM) to pressure, fluid, solute and ion flows, deformation and electrical fields are discussed. RESULTS: Similarities and differences in these quantities for the five types of loading are specifically noted. For example, it is noted that there is no practical mechanical loading condition that can be achieved in the laboratory to produce effects that are equal to the effects of osmotic pressure loading within the ECM. Some counter-intuitive effects from these loadings are also described. Further, the significance of flow-induced compression of the ECM is emphasized, since this frictional drag effect is likely to be one of the major effects of fluid flow through the porous-permeable ECM. Streaming potentials arising from the flow of ions past the fixed charges of the ECM are discussed in relation to the flow-induced compaction effect as well. CONCLUSION: Understanding the differences among these explant loading cases is important; it will help to provide greater insights to the mechano-electrochemical events which mediate metabolic responses of chondrocytes in explant loading experiments.
Authors:
V C Mow; C C Wang; C T Hung
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society     Volume:  7     ISSN:  1063-4584     ISO Abbreviation:  Osteoarthr. Cartil.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-06-28     Completed Date:  1999-06-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9305697     Medline TA:  Osteoarthritis Cartilage     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  41-58     Citation Subset:  IM; S    
Affiliation:
Orthopaedic Research Laboratory, Columbia University, New York, NY 10032, USA. vcm1@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Biomechanics
Cartilage, Articular / physiology*
Extracellular Space / physiology
Humans
Ion Transport / physiology
Osmotic Pressure
Signal Transduction / physiology*
Stress, Mechanical
Grant Support
ID/Acronym/Agency:
AR 41913/AR/NIAMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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