Document Detail


The extinction program for Homo sapiens and cloning humans: trinucleotide expansion as a one-way track to extinction.
MedLine Citation:
PMID:  11359350     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been uncovered that expansion of trinucleotide repeats in the human genome are causing a variety of genetic diseases. They are also identified in other loci that are not clearly related to particular diseases, which indicates such repeat expansion is one of the general forms of evolution occurring throughout the human genome. Trinucleotide repeat expansion has been shown to occur during meiosis, and is generally irreversible. In consequence, every human chromosome suffers from the burden of accumulating trinucleotide repeats along with the passage of generation, which eventually ends up in a deficiency of replication. Thus, all the human chromosomes are predicted to be 'mortal', so far as they replicate through meiosis. Naturally, the mortality of human chromosomes leads to the mortality of Homo sapiens as a species on earth. Although it is quite controversial, a radical breakthrough for humans to survive might be found through cloning reproduction without meiosis.
Authors:
S Kubota
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  56     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-05-21     Completed Date:  2001-07-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  296-301     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Harcourt Publishers Ltd.
Affiliation:
The Dorrance H. Hamilton Laboratories, Division of Infectious Diseases, Department of Medicine, Center for Human Virology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. kubota1@dent.okayama-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromosomes, Human / genetics,  physiology
Cloning, Organism*
Evolution*
Hominidae / genetics*
Humans
Models, Genetic
Trinucleotide Repeat Expansion / genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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