Document Detail


The extent of the specialized atrioventricular ring tissues.
MedLine Citation:
PMID:  19328044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The so-called specialized tissues within the heart are the sinus node, the atrioventricular conduction system, and the Purkinje network. Further structures with the characteristics of specialized tissue are also found within the atrioventricular junction, although they are less well described. OBJECTIVE: The purpose of this study was to demonstrate the location and extent of these atrioventricular ring specialized tissues, showing their relationship with the normal atrioventricular conduction system. METHODS: We identified the tissues using histology combined with immunohistochemical labeling with connexin43 (Cx43), the major gap junction in heart, and HCN4, the major isoform of the funny channel. RESULTS: We observed rings of specialized tissue mainly in hearts from rats, mice, and guinea pigs, negative for Cx43 but positive for HCN4. Each ring takes its origin from an inferior extension of the atrioventricular node. The rightward ring runs around the vestibule of the tricuspid valve, whereas the leftward ring encircles the mitral valve. On returning toward the atrial septum, the tricuspid ring crosses over the penetrating part of the atrioventricular conduction system, reuniting with the mitral ring to form a superiorly located retroaortic node. The atrioventricular conduction system itself continues beyond the origin of the right and left bundle branches, forming an aortic ring that ascends toward the retroaortic node but fails to make contact because of the intervening area of aortic-to-mitral valvar fibrous continuity. CONCLUSION: Rings of conduction tissue take their origin from inferior extensions of the atrioventricular node, passing rightward and leftward to encircle the orifices of the tricuspid and mitral valves and reuniting to form an extensive retroaortic node. Thus, a ring with morphologic features justifying a definition of specialized conduction tissue surrounds the atrioventricular junctions, although its function has yet to be established.
Authors:
Joseph Yanni; Mark R Boyett; Robert H Anderson; Halina Dobrzynski
Related Documents :
3976524 - Small left atrium and change in contour of the ventricular septum in total anomalous pu...
431124 - The right ventricular myocardium in ebstein's anomaly: a morphometric histopathologic s...
564244 - Apex echocardiography. a two-dimensional technique for evaluating congenital heart dise...
7431984 - Is tricuspid valve repair necessary?
1087564 - Use of noninvasive methods in evaluation of left ventricular performance in coronary ar...
19039214 - Basilar artery dolichoectasia is associated with paramedian pontine infarction.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-21
Journal Detail:
Title:  Heart rhythm : the official journal of the Heart Rhythm Society     Volume:  6     ISSN:  1556-3871     ISO Abbreviation:  Heart Rhythm     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-24     Completed Date:  2009-08-25     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  101200317     Medline TA:  Heart Rhythm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  672-80     Citation Subset:  IM    
Affiliation:
Cardiovascular Research Group, Faculty of Medical and Human Sciences, University of Manchester, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Thoracic / cytology,  innervation*,  metabolism
Atrioventricular Node / cytology*,  metabolism
Bundle of His / cytology*,  metabolism
Caveolin 3 / metabolism
Cell Size
Connexin 43 / metabolism
Cyclic Nucleotide-Gated Cation Channels / metabolism
Guinea Pigs
Immunohistochemistry
Male
Mice
Potassium Channels / metabolism
Rats
Rats, Wistar
Grant Support
ID/Acronym/Agency:
//British Heart Foundation
Chemical
Reg. No./Substance:
0/Caveolin 3; 0/Connexin 43; 0/Cyclic Nucleotide-Gated Cation Channels; 0/HCN3 protein, mouse; 0/HCN4 protein, rat; 0/Potassium Channels
Comments/Corrections
Comment In:
Heart Rhythm. 2009 May;6(5):681-3   [PMID:  19389654 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Epicardial ablation eliminates ventricular arrhythmias in an experimental model of Brugada syndrome.
Next Document:  Synthetic and endogenous beta-adrenergic receptor antagonists--comparative pharmacological character...