Document Detail


The extent and pattern of gastro-oesophageal reflux in patients with scleroderma oesophagus: the effect of low-dose omeprazole.
MedLine Citation:
PMID:  8280819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ambulatory 24-hour oesophageal pH studies were obtained from 11 patients with scleroderma who expressed either dysphagia (n = 6) or heartburn (n = 5) as their predominant oesophageal symptom. No significant differences were found in the extent of pattern of reflux between these two groups. The pH data of both scleroderma groups were combined and compared to an age- and sex-matched group of control subjects (n = 11). The reflux demonstrated by scleroderma patients was significantly greater than the control group in every category (P < 0.01). The percentage of time the pH was < 4.0 was not significantly different (P > 0.05) upright (29.9 +/- 19.8%) vs. supine (44.2 +/- 28.5%) in patients with scleroderma. Eight scleroderma patients underwent repeat pH studies while taking low-dose omeprazole (20 mg daily) and reflux was reduced significantly (P < 0.01) in all patients. The authors believe that 24-hour ambulatory oesophageal pH-monitoring should be routinely conducted in scleroderma patients to provide quantitative reflux data, even when heartburn is not expressed as a symptom. Omeprazole, 20 mg daily, provides adequate protection from the H+ component of the refluxate.
Authors:
J P Shoenut; J A Wieler; A B Micflikier
Related Documents :
15473409 - Echocardiographic and clinical characteristics of pulmonary hypertension complicating p...
16598989 - Laryngopharyngeal reflux.
20920599 - Esophageal eosinophilic infiltration responds to proton pump inhibition in most adults.
21139539 - Upper and lower gastrointestinal causes of iron deficiency anemia in elderly compared w...
9278669 - Oesophageal and cardia function in patients with paraoesophageal hiatus hernia.
19638089 - Reflux profile of chinese gastroesophageal reflux disease patients with combined multic...
22426499 - Risk factors for osteoporosis in caucasian patients with moderate chronic obstructive p...
2702569 - Subacute brain atrophy after radiation therapy for malignant brain tumor.
2748769 - Correlates of mitral valve prolapse among patients with panic disorder.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  7     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-02-15     Completed Date:  1994-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  509-13     Citation Subset:  IM    
Affiliation:
St Boniface General Hospital, Department of Medicine, Winnipeg, Manitoba, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Deglutition Disorders / etiology
Dose-Response Relationship, Drug
Esophagus / metabolism
Female
Gastroesophageal Reflux / drug therapy*,  etiology*
Heartburn / etiology
Humans
Hydrogen-Ion Concentration
Male
Middle Aged
Omeprazole / administration & dosage,  therapeutic use*
Prospective Studies
Scleroderma, Systemic / complications*
Chemical
Reg. No./Substance:
73590-58-6/Omeprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Does 40 mg omeprazole daily offer additional benefit over 20 mg daily in patients requiring more tha...
Next Document:  A prospective randomized study with mineral oil and oral lavage solution for treatment of faecal imp...