| An extended commentary on "Models and regulatory considerations for transient temperature rise during diagnostic ultrasound pulses" by Herman and Harris (2002). | |
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MedLine Citation:
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PMID: 14654160 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This commentary addresses the matter of misinterpretation of thermal dose as discussed by Herman and Harris (2002), and shows that the thermal doses they would consider as ineffective (i.e., "safe") for producing a hyperthermia-induced teratologic effect, can be highly effective ones. The matter of whether or not thermal thresholds exist for teratologic effects is reviewed. There are only opinions about thresholds. The critical experiments for ascertaining whether or not a threshold exists have not been undertaken. A power computation illustrates the requisite sample sizes (litters, fetuses) for undertaking an experimental test of whether the hyperthermic teratologic response in rats is characterized by threshold or simple linearity kinetics. |
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Authors:
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Morton W Miller; William C Dewey |
Publication Detail:
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Type: Comment; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Ultrasound in medicine & biology Volume: 29 ISSN: 0301-5629 ISO Abbreviation: Ultrasound Med Biol Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-12-05 Completed Date: 2004-02-05 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 1653-9; author response 1661-2 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA. Morton_Miller@urmc.rochester.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Computational Biology Congenital Abnormalities / etiology* Female Guinea Pigs Hot Temperature* Humans Models, Biological Pregnancy Rats Sample Size Time Factors Ultrasonography, Prenatal / adverse effects* |
| Grant Support | |
ID/Acronym/Agency:
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R03 HD37669-02/HD/NICHD NIH HHS; R37 CA39230-28/CA/NCI NIH HHS; R37 EB00213-28/EB/NIBIB NIH HHS |
| Comments/Corrections | |
Comment On:
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Ultrasound Med Biol. 2002 Sep;28(9):1217-24
[PMID:
12401393
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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