Document Detail

The expressions of inflammatory factors and tissue inhibitor of matrix metalloproteinase-2 in human chronic periodontitis with type 2 diabetes mellitus.
MedLine Citation:
PMID:  20498757     Owner:  NLM     Status:  PubMed-not-MEDLINE    
PURPOSE: The purpose of this study was to observe and quantify the expression of interleukin-4 (IL-4), interferon-gamma (IFN-gamma), and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) in the gingival tissue of patients with type 2 diabetes mellitus (DM) and healthy adults with chronic periodontitis.
METHODS: Twelve patients with type 2 DM and chronic periodontitis (Group 3), twelve patients with chronic periodontitis (Group 2), and twelve healthy individuals (Group 1) were included in the study. Clinical criteria of gingival (sulcus bleeding index value, probing depths) and radiographic evidences of bone resorption were divided into three groups. The concentrations of cytokines were determined by a western blot analysis and compared using one-way ANOVA followed by Tukey's test.
RESULTS: The expression levels of IFN-gamma and TIMP-2 showed an increasing tendency in Groups 2 and 3 when compared to Group 1. On the other hand, the expression of IL-4 was highest in Group 1.
CONCLUSIONS: The findings suggest that IFN-gamma and TIMP-2 may be involved in the periodontal inflammation associated with type 2 DM. IL-4 may be involved in the retrogression of the periodontal inflammation associated with type 2 DM.
Dong-Seok Shin; Jin-Woo Park; Jo-Young Suh; Jae-Mok Lee
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Publication Detail:
Type:  Journal Article     Date:  2010-02-28
Journal Detail:
Title:  Journal of periodontal & implant science     Volume:  40     ISSN:  2093-2286     ISO Abbreviation:  J Periodontal Implant Sci     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-05-25     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101526931     Medline TA:  J Periodontal Implant Sci     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  33-8     Citation Subset:  -    
Department of Periodontology, Kyungpook National University School of Dentistry, Daegu, Korea.
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