| The expression of thioredoxin mRNA is increased in the human cervix during pregnancy. | |
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MedLine Citation:
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PMID: 9464857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The classic function for thioredoxin is to act as a hydrogen donor for the enzyme ribonucleotide reductase, which is essential for DNA synthesis. In addition, thioredoxin participates in the regulation of different metabolic processes via thiol redox control. These kind of processes involve changes in the activity of different enzymes, receptors or transcription factors via dithiol/disulphide interchange reactions. Thioredoxin is present in the human decidua and trophoblasts. This study was performed to investigate whether thioredoxin mRNA is present in the human cervix, and differently expressed during pregnancy as compared with the non-pregnant state. Cervical biopsies and serum samples were obtained from 28 late pregnant, 41 post-partum and 15 non-pregnant menstruating women. The tissues were analysed for thioredoxin mRNA content using a solution hybridization technique. The thioredoxin mRNA level increased 3-fold at late pregnancy in comparison with the non-pregnant state. No further increase was seen immediately after parturition, either after spontaneous delivery or after pharmacological induction. There was a positive correlation between the cervical thioredoxin mRNA level and the serum oestradiol concentration in the non-pregnant group. We suggest that thioredoxin mRNA in the human cervix is regulated, at least partly, by oestradiol. |
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Authors:
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L Sahlin; Y Stjernholm; A Holmgren; G Ekman; H Eriksson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular human reproduction Volume: 3 ISSN: 1360-9947 ISO Abbreviation: Mol. Hum. Reprod. Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-03-10 Completed Date: 1998-03-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9513710 Medline TA: Mol Hum Reprod Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1113-7 Citation Subset: IM |
Affiliation:
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Department of Woman and Child Health, Karolinska Hospital, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Cervix Uteri / enzymology, metabolism* Estradiol / blood Female Humans Middle Aged Pregnancy Progesterone / blood Protein Disulfide Reductase (Glutathione) / metabolism RNA, Messenger / biosynthesis* Thioredoxins / biosynthesis*, genetics* |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 50-28-2/Estradiol; 52500-60-4/Thioredoxins; 57-83-0/Progesterone; EC 1.8.4.2/Protein Disulfide Reductase (Glutathione) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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