Document Detail

The expression of retinoic acid receptors in lymph nodes of young children and the effect of all-trans-retinoic acid on the B cells from lymph nodes.
MedLine Citation:
PMID:  17216566     Owner:  NLM     Status:  MEDLINE    
To elucidate the mechanism of vitamin A enhancing the production of antibody, we examined the expression and distribution of retinoic acid receptors mRNA in lymph nodes of young children ( < or = 5 years of age), and investigated the affection of all-trans-retinoic acid on the maturation and activation of the B cells isolated from the lymph nodes and cultured in vitro. Twenty-four normal lymph nodes were collected. By in situ hybridization, we found that all six retinoic acid receptor genes expressed and distributed widely in the lymph nodes, and the levels of mRNA for retinoic acid receptor genes (detected by RT-fluorescent quantitative PCR) were increased with the development of children. In vitro culture, all-trans retinoic acid promoted the maturation and activation of the B cells from the lymph nodes. Thus, promotion on B cells in lymph node may be the important mechanism of vitamin A reinforcing the humoral immunity in young children.
Dong Wei; Yi Yang; Weiping Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-11
Journal Detail:
Title:  Journal of clinical immunology     Volume:  27     ISSN:  0271-9142     ISO Abbreviation:  J. Clin. Immunol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-02-08     Completed Date:  2007-05-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102137     Medline TA:  J Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  88-94     Citation Subset:  IM    
Children's Hospital, Pediatrics Department of Shanghai Medical College, Fudan University, Shanghai, P.R. China.
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MeSH Terms
Age Factors
Antibody Formation / drug effects,  immunology
B-Lymphocytes / metabolism*
Cells, Cultured
Child, Preschool
Gene Expression Regulation / physiology
In Situ Hybridization
Lymph Nodes / drug effects,  metabolism*
RNA, Messenger / isolation & purification
Receptors, Retinoic Acid / genetics,  metabolism*
Reverse Transcriptase Polymerase Chain Reaction
Tretinoin / metabolism*,  pharmacology*
Reg. No./Substance:
0/RNA, Messenger; 0/Receptors, Retinoic Acid; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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