Document Detail

The expression of a progesterone-induced immunomodulatory protein in pregnancy lymphocytes.
MedLine Citation:
PMID:  8607938     Owner:  NLM     Status:  MEDLINE    
PROBLEM: The immunological effects of progesterone are mediated by a protein, named the progesterone-induced blocking factor (PIBF). The PIBF blocks NK activity in vitro and therefore prevents the abortive effect on high NK activity in mice. Increased NK activity has been suggested to play a role in pregnancy termination; thus NK inhibitory effect of the PIBF should contribute to the maintenance of normal gestation. This study was designed to investigate the relationship between n vivo PIBF-producing capacity and in vitro cytotoxic activity of pregnancy lymphocytes, as well as the clinical status or the outcome of pregnancy. METHOD: Lymphocytes of 168 pregnant women (96 normal pregnancies, 16 showing clinical symptoms of threatened preterm pregnancy termination, 46 recurrent aborters, and 10 women sampled at the onset of spontaneous abortion or preterm delivery) were isolated on Ficoll-Paque gradient. The lymphocytes were tested for reactivity with a PIBF-specific antibody by immunocytochemistry, and simultaneously for cytotoxic activity to human embryonic fibroblast targets. RESULTS: The percentage of PIBF-positive lymphocytes in peripheral blood of healthy pregnant women was significantly higher than in that of women at risk for premature pregnancy termination. In peripheral blood of patients undergoing spontaneous pregnancy termination at the time of sampling, and in those of women showing symptoms of premature pregnancy termination we found lower than normal percentage of PIBF-positive cells. PIBF expression of the lymphocytes showed an inverse correlation with NK activity, and the rate of PIBF positive lymphocytes was related to the outcome of pregnancy. CONCLUSION: These data suggest a strong relationship between PIBF producing capacity as well as NK activity of the lymphocytes and the success of gestation.
J Szekeres-Bartho; Z Faust; P Varga
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  34     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-05-30     Completed Date:  1996-05-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  342-8     Citation Subset:  IM    
Department of Microbiology, University Medical School of Pecs, Hungary.
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MeSH Terms
Abortion, Spontaneous / blood,  immunology
Adjuvants, Immunologic / blood*
Antibodies, Blocking / pharmacology
Cytotoxicity, Immunologic
Killer Cells, Natural / drug effects,  immunology
Lymphocytes / drug effects*,  immunology*
Obstetric Labor, Premature / blood,  immunology
Pregnancy / immunology*
Pregnancy Maintenance / immunology
Pregnancy Outcome
Pregnancy Proteins / blood*,  immunology*
Progesterone / pharmacology*
Suppressor Factors, Immunologic
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Antibodies, Blocking; 0/PIBF1 protein, human; 0/Pibf1 protein, mouse; 0/Pregnancy Proteins; 0/Suppressor Factors, Immunologic; 57-83-0/Progesterone

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