Document Detail

The expression of a novel stress protein '150-kDa oxygen regulated protein' in sudden infant death.
MedLine Citation:
PMID:  12935645     Owner:  NLM     Status:  MEDLINE    
The oxygen regulated protein 150-kDa (ORP-150) is only induced in hypoxic conditions. We performed an immunohistochemical and morphometrical study on the expression of ORP-150 in the brains of sudden infant death (SID) victims. The cerebral cortexes of 18 infants were used for this study. Each tissue section was incubated with anti-ORP-150 polyclonal antibodies and the number of ORP-150 positive cells was counted. In the cluster analysis, the 18 cases were classified into three groups (A-C groups). Group A was composed of six sudden infant death syndrome (SIDS) cases and its mean value of ORP-150 positive cells was 66.75+/-3.44, Group B (six severe respiratory infectious disease such as pneumonia and bronchitis including sepsis): 39.50+/-2.52 and Group C (five SIDS and one severe respiratory infectious disease): 16.00+/-2.92, respectively. These results might reflect chronic hypoxic condition before death, because ORP-150 is only induced when a hypoxic condition exist, but not acute hypoxia. And chronic hypoxic state is likely to be antecedent to SIDS. Therefore, immunohistochemical analysis of OPR-150 in the brain of SID cases may be very useful to differentiate between SIDS and acute asphyxia.
Kazuya Ikematsu; Ryouichi Tsuda; Toshikazu Kondo; Hisayoshi Kondo; Kentaro Ozawa; Satoshi Ogawa; Ichiro Nakasono
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Legal medicine (Tokyo, Japan)     Volume:  5     ISSN:  1344-6223     ISO Abbreviation:  Leg Med (Tokyo)     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-08-25     Completed Date:  2003-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100889186     Medline TA:  Leg Med (Tokyo)     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  15-9     Citation Subset:  IM    
Division of Forensic Pathology and Science, Department of Translational Medical Sciences, Course of Medical and Dental Sciences, Graduate School of Biochemical Sciences, Nagasaki University, Nagasaki City, Nagasaki 852-8523, Japan.
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MeSH Terms
Cerebral Cortex / metabolism
Infant, Newborn
Proteins / metabolism*
Sudden Infant Death*
Reg. No./Substance:
0/Proteins; 0/oxygen-regulated proteins

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