| The expression of a novel stress protein '150-kDa oxygen regulated protein' in sudden infant death. | |
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MedLine Citation:
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PMID: 12935645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The oxygen regulated protein 150-kDa (ORP-150) is only induced in hypoxic conditions. We performed an immunohistochemical and morphometrical study on the expression of ORP-150 in the brains of sudden infant death (SID) victims. The cerebral cortexes of 18 infants were used for this study. Each tissue section was incubated with anti-ORP-150 polyclonal antibodies and the number of ORP-150 positive cells was counted. In the cluster analysis, the 18 cases were classified into three groups (A-C groups). Group A was composed of six sudden infant death syndrome (SIDS) cases and its mean value of ORP-150 positive cells was 66.75+/-3.44, Group B (six severe respiratory infectious disease such as pneumonia and bronchitis including sepsis): 39.50+/-2.52 and Group C (five SIDS and one severe respiratory infectious disease): 16.00+/-2.92, respectively. These results might reflect chronic hypoxic condition before death, because ORP-150 is only induced when a hypoxic condition exist, but not acute hypoxia. And chronic hypoxic state is likely to be antecedent to SIDS. Therefore, immunohistochemical analysis of OPR-150 in the brain of SID cases may be very useful to differentiate between SIDS and acute asphyxia. |
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Authors:
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Kazuya Ikematsu; Ryouichi Tsuda; Toshikazu Kondo; Hisayoshi Kondo; Kentaro Ozawa; Satoshi Ogawa; Ichiro Nakasono |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Legal medicine (Tokyo, Japan) Volume: 5 ISSN: 1344-6223 ISO Abbreviation: Leg Med (Tokyo) Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-08-25 Completed Date: 2003-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100889186 Medline TA: Leg Med (Tokyo) Country: Ireland |
Other Details:
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Languages: eng Pagination: 15-9 Citation Subset: IM |
Affiliation:
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Division of Forensic Pathology and Science, Department of Translational Medical Sciences, Course of Medical and Dental Sciences, Graduate School of Biochemical Sciences, Nagasaki University, Nagasaki City, Nagasaki 852-8523, Japan. k-ikema@remus.dti.ne.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Autopsy Cerebral Cortex / metabolism Humans Immunohistochemistry Infant Infant, Newborn Proteins / metabolism* Sudden Infant Death* |
| Chemical | |
Reg. No./Substance:
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0/Proteins; 0/oxygen-regulated proteins |
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