Document Detail


The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation.
MedLine Citation:
PMID:  9070329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the expression of Zic1, Zic2, and Zic3 genes in the mouse embryo by means of in situ hybridization. Zic genes were found as a group of genes coding for zinc finger proteins that are expressed in a restricted manner in the adult mouse cerebellum. We showed that the genes are the vertebrate homologues of Drosophila odd-paired, which may play an essential role in parasegmental subdivision and in visceral mesoderm development. The expression of the three Zic genes was first detected at gastrulation in a spatially restricted manner. At neurulation, the expression became restricted to the dorsal neural ectoderm and dorsal paraxial mesoderm. During organogenesis, the three genes were expressed in specific regions of several developing organs, including dorsal areas of the brain, spinal cord, paraxial mesenchyme, and epidermis, the marginal zone of the neural retina and distal regions of the developing limb. For all stages, significant differences in the spatial expression of Zic1, Zic2, and Zic3 were observed. Furthermore, the expression of Zic genes in Pax3, Wnt-1, and Wnt-3a mutant embryos suggested that Zic genes are not primarily regulated by the three genes which were expressed in dorsal areas similar to Zic genes. However, in open brain, a mutant with severe neural tube defects, and in the Wnt-3a mutant mice, the expression of Zic genes was changed. The changed expression pattern in Wnt-3a mutant mice suggests that Zic genes in the neural tube are regulated by the factors from notochord. Our findings suggest that Zic genes are involved in many developmental processes. Furthermore, analysis of gene expression patterns in different mouse mutants indicated that Zic genes may act upstream of many known developmental regulatory genes.
Authors:
T Nagai; J Aruga; S Takada; T Günther; R Spörle; K Schughart; K Mikoshiba
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental biology     Volume:  182     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-04-07     Completed Date:  1997-04-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  299-313     Citation Subset:  IM    
Affiliation:
Molecular Neurobiology Laboratory, Tsukuba Life Science Center, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning / genetics*
DNA-Binding Proteins / genetics
Drosophila / embryology,  genetics
Drosophila Proteins*
Embryonic and Fetal Development / genetics
Extremities / embryology
Eye / embryology
Gastrula
Gene Expression
Gene Expression Regulation, Developmental*
Homeodomain Proteins / genetics
In Situ Hybridization
Mice
Neural Tube Defects / genetics
Paired Box Transcription Factors
Proteins / genetics
Proto-Oncogene Proteins / genetics
Transcription Factors / genetics
Wnt Proteins
Wnt1 Protein
Zebrafish Proteins*
Zinc Fingers / genetics*,  physiology
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Homeodomain Proteins; 0/Opa protein, Drosophila; 0/Paired Box Transcription Factors; 0/Proteins; 0/Proto-Oncogene Proteins; 0/Transcription Factors; 0/Wnt Proteins; 0/Wnt-3 protein; 0/Wnt1 Protein; 0/Wnt1 protein, mouse; 0/Zebrafish Proteins; 0/pax3 protein, zebrafish; 138016-91-8/Pax3 protein, mouse

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