Document Detail


The expression of leucine-rich repeat gene family members in colorectal cancer.
MedLine Citation:
PMID:  23045723     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was conducted to evaluate the association of the leucine-rich repeat (LRR) gene family with colorectal cancer (CRC). The expression of members of the LRR gene family were analyzed in 17 CRC specimens and in 59 healthy colorectal tissues by using Human Exon1.0ST microarray, and in 25 CRC specimens and 32 healthy colorectal tissues by U133Plus2.0 microarray. An association was found for 25 genes belonging to the plant-specific (PS) class of LRR genes (P = 0.05 for Exon1.0 ST and P = 0.04 for U133Plus2.0). In both data-sets, in CRC, we found down-regulation of SHOC2 (P < 0.00003) and LRRC28 (P < 0.01) and up-regulation of LRSAM1 (P < 0.000001), while up-regulation of MFHAS1 (P = 0.0005) and down-regulation of WDFY3 (P = 0.026) were found only in the Exon1.0 ST data-set. The PS LLR gene class encodes proteins that activate immune cells and might play a key role in programmed cell death and autophagy. SHOC2 and LRRC28 genes involved in RAS-mediated signaling, which hinders nutrient deprivation-induced autophagy, might be a possible link between the negative control of autophagy and tumorigenesis.
Authors:
Ada Piepoli; Orazio Palmieri; Rosalia Maglietta; Anna Panza; Elisa Cattaneo; Anna Latiano; Endre Laczko; Annamaria Gentile; Massimo Carella; Gianluigi Mazzoccoli; Nicola Ancona; Giancarlo Marra; Angelo Andriulli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-08
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  237     ISSN:  1535-3699     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-01     Completed Date:  2013-02-05     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1123-8     Citation Subset:  IM    
Affiliation:
Laboratory and Division of Gastroenterology, IRCCS Casa Sollievo della Sofferenza Hospital, Viale Cappuccini n.1, San Giovanni Rotondo (FG), Italy. a.piepoli@operapadrepio.it
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MeSH Terms
Descriptor/Qualifier:
Autophagy
Cell Cycle Proteins / genetics,  metabolism
Colorectal Neoplasms / genetics,  metabolism*
DNA-Binding Proteins / genetics,  metabolism
Exons
Gene Expression Profiling*
Gene Expression Regulation
Humans
Intracellular Signaling Peptides and Proteins / genetics,  metabolism
Leucine / genetics*
Membrane Proteins / genetics,  metabolism
Oncogene Proteins / genetics,  metabolism
Protein Array Analysis
Signal Transduction
Transcription Factors / genetics,  metabolism
Ubiquitin-Protein Ligases / genetics,  metabolism
Chemical
Reg. No./Substance:
0/Cell Cycle Proteins; 0/DNA-Binding Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/MFHAS1 protein, human; 0/Membrane Proteins; 0/Oncogene Proteins; 0/SHOC2 protein, human; 0/Transcription Factors; 0/WDFY3 protein, human; 61-90-5/Leucine; EC 6.3.2.19/LRSAM1 protein, human; EC 6.3.2.19/Ubiquitin-Protein Ligases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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