| Is the expression of gamma-glutamyl transpeptidase messenger RNA an indicator of biological behavior in recurrent hepatocellular carcinoma? | |
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MedLine Citation:
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PMID: 12632499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To investigate the correlation between gamma-glutamyl transpeptidase (gamma-GTP) expression in the primary HCC and post-resection recurrence and its biological behaviors. METHODS: Forty consecutive patients having curative resection for HCC were included in this study. The primers for reverse-transcription polymerase chain reaction (RT-PCR) were corresponding to the 5'-noncoding human gamma-GTP mRNA of fetal liver (type A), HepG2 cells (type B), and placenta (type C). Both the cancer and non-cancerous tissues of the resected liver were analyzed. The correlations between the expression of gamma-GTP and the clinicopathological variables and outcomes (recurrence and survival) were studied. RESULTS: Those with type B gamma-GTP mRNA in cancer had significant higher recurrence rate than those without it (63.6 % vs 14.3 %). Both those with type B in cancer and in non-cancer died significantly more than those without it (45.5 % vs 0 % and 53.6 % vs 0 %, respectively). By multivariate analysis, the significant predictors of recurrence included high serum AFP (P=0.0108), vascular permeation (P=0.0084), and type B gamma-GTP mRNA in non-cancerous liver (P=0.0107). The significant predictors of post-recurrence death included high serum AFP (P=0.0141), vascular permeation (P=0.0130), and daughter nodules (P=0.0053). As to the manifestations (recurrent number >=2, recurrent extent >=2 segments, extra-hepatic metastasis, and death) in recurrent patients, there were no statistical significant differences between those with type B in the primary tumor and those without it. The difference between those with type B in non-cancerous liver and those without it also was not significant. CONCLUSION: Patients of HCC with type B gamma-GTP mRNA both in cancer and in non-cancerous tissue had a worse outcome, earlier recurrence, and more post-recurrence death. |
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Authors:
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I-Shyan Sheen; Kuo-Shyang Jeng; Yi-Chun Tsai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 9 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-12 Completed Date: 2003-04-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 468-73 Citation Subset: IM |
Affiliation:
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Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Carcinoma, Hepatocellular / physiopathology*, surgery* Female Humans Isoenzymes / genetics, metabolism Liver Neoplasms / physiopathology*, surgery* Male Middle Aged Neoplasm Recurrence, Local / physiopathology* RNA, Messenger / metabolism gamma-Glutamyltransferase / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; 0/RNA, Messenger; EC 2.3.2.2/gamma-Glutamyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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