| The expression of fucose isoforms of amniotic and plasma alpha-1-acid glycoprotein derived from 2nd and 3rd trimester normal pregnancies. | |
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MedLine Citation:
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PMID: 19616527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To analyse modifications in AGP fucosylation in relation to different stages of human pregnancy. DESIGN AND METHODS: The relative amounts of three fucosyl-glycotopes on AGP were analysed by lectin-ELISA using fucose-specific biotinylated lectins in 169 plasma and 178 amniotic fluid samples from normal pregnancies with gestational ages of 14 to 42 weeks. RESULTS: The plasma AGPs of all the pregnant women and amniotic AGPs from the 2nd trimester lacked fucoses. In contrast, in the 3rd trimester the amniotic AGPs were highly decorated by the innermost alpha1,6-fucose as well as alpha1,2- and alpha1,3-fucoses of the outer arms, reaching the highest expression around the perinatal period. At delivery the relative amounts of the alpha1,3- and alpha1,2-AGP isoforms, but not the alpha1,6 isoform, significantly decreased. CONCLUSIONS: The highly fucosylated amniotic AGP isoforms could be implicated in regulatory processes to ensure homeostasis during pregnancy and to protect the fetus. They have the potential of becoming laboratory markers in obstetrics to monitor pregnancy. |
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Authors:
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Magdalena Orczyk-Pawi??owicz; Lidia Hirnle; Iwona Katnik-Prastowska |
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Publication Detail:
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Type: Journal Article Date: 2009-07-17 |
Journal Detail:
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Title: Clinical biochemistry Volume: 42 ISSN: 1873-2933 ISO Abbreviation: Clin. Biochem. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-21 Completed Date: 2009-12-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 1517-23 Citation Subset: IM |
Affiliation:
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Department of Chemistry and Immunochemistry, Wroc??aw, Wroc??aw Medical University, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniotic Fluid / chemistry* Female Fucose / chemistry, metabolism* Glycosylation Humans Infant, Newborn Lectins / metabolism Orosomucoid* / chemistry, metabolism Pregnancy Pregnancy Trimester, Second / metabolism* Pregnancy Trimester, Third / metabolism* Protein Isoforms / metabolism* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Lectins; 0/Orosomucoid; 0/Protein Isoforms; 3713-31-3/Fucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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