| The expression of fibroblast growth factor receptor-3 in synovial osteochondromatosis of the temporomandibular joint. | |
MedLine Citation:
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PMID: 15126141 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary synovial osteochondromatosis (PSC) is a disease of unknown aetiology. It was reported recently that expression of fibroblast growth factor receptor-3 (FGFR-3) was observed specifically in PSC. We classified six cases of synovial osteochondromatosis (SC) of the temporomandibular joint (TMJ) into two types of SC, PSC (five cases) and secondary synovial osteochondromatosis (SSC) (one case), by means of clinical findings and haematoxylin and eosin stain. The five PSC cases were classified into three different phases according to Milgram's classification. Immunohistochemical staining of FGFR-3 was carried out for each SC case, along with specimens of internal derangement (ID) of the TMJ, and normal articular disc and synovial membrane. FGFR-3 was found in all three phases of PSC, but not in SSC, ID or normal TMJ. Moreover, in a comparison between cultured synovial cells of PSC (Phase III) and ID, reverse transcription-polymerase chain reaction revealed a stronger positive reaction in PSC. These results indicate that the synovial membrane in Phase III PSC can produce cartilage nodules, as in Phases I and II. |
Authors:
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Itaru Tojyo; Akihiko Yamaguti; Harumi Ozaki; Hiroaki Yoshida; Shigeyuki Fujita |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of oral biology Volume: 49 ISSN: 0003-9969 ISO Abbreviation: Arch. Oral Biol. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-05-05 Completed Date: 2004-10-14 Revised Date: 2012-06-05 |
Medline Journal Info:
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Nlm Unique ID: 0116711 Medline TA: Arch Oral Biol Country: England |
Other Details:
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Languages: eng Pagination: 591-4 Citation Subset: D; IM |
Affiliation:
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Department of Oral and Maxillofacial Surgery, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8509, Japan. kagoky@wakayama-med.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cells, Cultured Chondromatosis, Synovial / metabolism* Humans Immunohistochemistry / methods Middle Aged Protein-Tyrosine Kinases / analysis* Receptor, Fibroblast Growth Factor, Type 3 Receptors, Fibroblast Growth Factor / analysis* Reverse Transcriptase Polymerase Chain Reaction / methods Synovial Membrane / metabolism Temporomandibular Joint / metabolism Temporomandibular Joint Disorders / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Fibroblast Growth Factor; EC 2.7.10.1/FGFR3 protein, human; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.1/Receptor, Fibroblast Growth Factor, Type 3 |
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