Document Detail

The expression of fibroblast growth factor receptor-3 in synovial osteochondromatosis of the temporomandibular joint.
MedLine Citation:
PMID:  15126141     Owner:  NLM     Status:  MEDLINE    
Primary synovial osteochondromatosis (PSC) is a disease of unknown aetiology. It was reported recently that expression of fibroblast growth factor receptor-3 (FGFR-3) was observed specifically in PSC. We classified six cases of synovial osteochondromatosis (SC) of the temporomandibular joint (TMJ) into two types of SC, PSC (five cases) and secondary synovial osteochondromatosis (SSC) (one case), by means of clinical findings and haematoxylin and eosin stain. The five PSC cases were classified into three different phases according to Milgram's classification. Immunohistochemical staining of FGFR-3 was carried out for each SC case, along with specimens of internal derangement (ID) of the TMJ, and normal articular disc and synovial membrane. FGFR-3 was found in all three phases of PSC, but not in SSC, ID or normal TMJ. Moreover, in a comparison between cultured synovial cells of PSC (Phase III) and ID, reverse transcription-polymerase chain reaction revealed a stronger positive reaction in PSC. These results indicate that the synovial membrane in Phase III PSC can produce cartilage nodules, as in Phases I and II.
Itaru Tojyo; Akihiko Yamaguti; Harumi Ozaki; Hiroaki Yoshida; Shigeyuki Fujita
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of oral biology     Volume:  49     ISSN:  0003-9969     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-05-05     Completed Date:  2004-10-14     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  591-4     Citation Subset:  D; IM    
Department of Oral and Maxillofacial Surgery, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8509, Japan.
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MeSH Terms
Cells, Cultured
Chondromatosis, Synovial / metabolism*
Immunohistochemistry / methods
Middle Aged
Protein-Tyrosine Kinases / analysis*
Receptor, Fibroblast Growth Factor, Type 3
Receptors, Fibroblast Growth Factor / analysis*
Reverse Transcriptase Polymerase Chain Reaction / methods
Synovial Membrane / metabolism
Temporomandibular Joint / metabolism
Temporomandibular Joint Disorders / metabolism*
Reg. No./Substance:
0/Receptors, Fibroblast Growth Factor; EC protein, human; EC Kinases; EC, Fibroblast Growth Factor, Type 3

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