Document Detail

The expression and concentration of CD40 ligand in normal pregnancy and pre-eclampsia.
MedLine Citation:
PMID:  19201484     Owner:  NLM     Status:  MEDLINE    
This study investigated the surface expression of the CD154 antigen (CD40L) on peripheral blood CD4+ T lymphocytes and the sera concentrations of soluble CD40L antigens (sCD40L) in non-pregnant women, normal pregnant women, and patients with pre-eclampsia. Twenty-five patients with pre-eclampsia, 18 healthy pregnant women, and 10 healthy non-pregnant women were included in the study. The expression of the CD154 antigen on CD4+ T lymphocytes was determined using flow cytometry. The serum concentration of sCD40L was measured using an ELISA. Statistical analysis was performed using the Mann-Whitney U and ANOVA tests. The expression of the CD154 antigen on CD4+ T lymphocytes and the serum concentration of soluble CD40L were significantly higher in pre-eclampsia than in normal pregnant women. In normal pregnancy the expression of the CD154 antigen on CD4+ T lymphocytes and the concentration of sCD40L were significantly lower than in non-pregnant women. We conclude that during normal pregnancy the levels of these inflammatory mediators are lower than in non-pregnant women. In pre-eclampsia the levels are higher than those in normal pregnancy, but stable compared with the non-pregnant state. These results suggest that in pre-eclampsia, there are disturbances in the mechanisms responsible for the decrease in innate immunity which occurs in normal pregnancy.
D Darmochwal-Kolarz; B Kolarz; A Surdacka; J Rolinski; B Leszczynska-Gorzelak; J Oleszczuk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-08
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  79     ISSN:  1872-7603     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-03-17     Completed Date:  2009-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  215-9     Citation Subset:  IM    
Department of Obstetrics and Perinatology, Medical University of Lublin, Lublin, Poland.
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MeSH Terms
CD40 Ligand / blood*,  metabolism
Case-Control Studies
Pre-Eclampsia / blood*
T-Lymphocytes / metabolism
Reg. No./Substance:
147205-72-9/CD40 Ligand

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