| The expression and concentration of CD40 ligand in normal pregnancy and pre-eclampsia. | |
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MedLine Citation:
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PMID: 19201484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated the surface expression of the CD154 antigen (CD40L) on peripheral blood CD4+ T lymphocytes and the sera concentrations of soluble CD40L antigens (sCD40L) in non-pregnant women, normal pregnant women, and patients with pre-eclampsia. Twenty-five patients with pre-eclampsia, 18 healthy pregnant women, and 10 healthy non-pregnant women were included in the study. The expression of the CD154 antigen on CD4+ T lymphocytes was determined using flow cytometry. The serum concentration of sCD40L was measured using an ELISA. Statistical analysis was performed using the Mann-Whitney U and ANOVA tests. The expression of the CD154 antigen on CD4+ T lymphocytes and the serum concentration of soluble CD40L were significantly higher in pre-eclampsia than in normal pregnant women. In normal pregnancy the expression of the CD154 antigen on CD4+ T lymphocytes and the concentration of sCD40L were significantly lower than in non-pregnant women. We conclude that during normal pregnancy the levels of these inflammatory mediators are lower than in non-pregnant women. In pre-eclampsia the levels are higher than those in normal pregnancy, but stable compared with the non-pregnant state. These results suggest that in pre-eclampsia, there are disturbances in the mechanisms responsible for the decrease in innate immunity which occurs in normal pregnancy. |
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Authors:
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D Darmochwal-Kolarz; B Kolarz; A Surdacka; J Rolinski; B Leszczynska-Gorzelak; J Oleszczuk |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-08 |
Journal Detail:
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Title: Journal of reproductive immunology Volume: 79 ISSN: 1872-7603 ISO Abbreviation: J. Reprod. Immunol. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-03-17 Completed Date: 2009-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8001906 Medline TA: J Reprod Immunol Country: Ireland |
Other Details:
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Languages: eng Pagination: 215-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Perinatology, Medical University of Lublin, Lublin, Poland. dorotak@mp.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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CD40 Ligand
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blood*,
metabolism Case-Control Studies Female Health* Humans Pre-Eclampsia / blood* Pregnancy T-Lymphocytes / metabolism |
| Chemical | |
Reg. No./Substance:
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147205-72-9/CD40 Ligand |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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