Document Detail


The expression of calcitonin, calcitonin gene-related peptide and somatostatin in the thyroids of rats of different ages.
MedLine Citation:
PMID:  14655148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using immunocytochemistry and in situ hybridisation expression of calcitonin, calcitonin gene-related peptide (CGRP) and somatostatin was examined in rat thyroids. The immunocytochemical reactions demonstrated the presence of the proteins under investigation at all stages of rat life. Calcitonin and CGRP produced the most numerous parafollicular cells, while somatostatin was present in a few cells only. The number of cells producing the above-mentioned hormones was found to increase in rats with the progressing of age. Hybridocytochemical techniques corroborated the results obtained using immunocytochemical techniques. The most numerous cells were found to contain mRNAs for calcitonin and CGRP. In the case of somatostatin, however, multiple parafollicular cells produced mRNA for the hormone but few cells demonstrated the presence of the corresponding protein.
Authors:
Jolanta Seidel; Maciej Zabel; Aldona Kasprzak; Rafał Spachacz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia morphologica     Volume:  62     ISSN:  0015-5659     ISO Abbreviation:  Folia Morphol. (Warsz)     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-12-05     Completed Date:  2004-01-14     Revised Date:  2006-06-23    
Medline Journal Info:
Nlm Unique ID:  0374620     Medline TA:  Folia Morphol (Warsz)     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  485-7     Citation Subset:  IM    
Affiliation:
Chair of Histology and Embryology, University of Medical Sciences, Poznań, Poland. jseidel@amp.edu.pl
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Calcitonin / genetics,  metabolism*
Calcitonin Gene-Related Peptide / genetics,  metabolism*
Cell Count
Immunohistochemistry
In Situ Hybridization
Male
RNA, Messenger / metabolism
Rats
Rats, Wistar
Somatostatin / genetics,  metabolism*
Thyroid Gland / anatomy & histology,  metabolism*
Chemical
Reg. No./Substance:
0/RNA, Messenger; 51110-01-1/Somatostatin; 83652-28-2/Calcitonin Gene-Related Peptide; 9007-12-9/Calcitonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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