| The expression of calcitonin, calcitonin gene-related peptide and somatostatin in the thyroids of rats of different ages. | |
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MedLine Citation:
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PMID: 14655148 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using immunocytochemistry and in situ hybridisation expression of calcitonin, calcitonin gene-related peptide (CGRP) and somatostatin was examined in rat thyroids. The immunocytochemical reactions demonstrated the presence of the proteins under investigation at all stages of rat life. Calcitonin and CGRP produced the most numerous parafollicular cells, while somatostatin was present in a few cells only. The number of cells producing the above-mentioned hormones was found to increase in rats with the progressing of age. Hybridocytochemical techniques corroborated the results obtained using immunocytochemical techniques. The most numerous cells were found to contain mRNAs for calcitonin and CGRP. In the case of somatostatin, however, multiple parafollicular cells produced mRNA for the hormone but few cells demonstrated the presence of the corresponding protein. |
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Authors:
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Jolanta Seidel; Maciej Zabel; Aldona Kasprzak; Rafał Spachacz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Folia morphologica Volume: 62 ISSN: 0015-5659 ISO Abbreviation: Folia Morphol. (Warsz) Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-12-05 Completed Date: 2004-01-14 Revised Date: 2006-06-23 |
Medline Journal Info:
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Nlm Unique ID: 0374620 Medline TA: Folia Morphol (Warsz) Country: Poland |
Other Details:
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Languages: eng Pagination: 485-7 Citation Subset: IM |
Affiliation:
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Chair of Histology and Embryology, University of Medical Sciences, Poznań, Poland. jseidel@amp.edu.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Calcitonin / genetics, metabolism* Calcitonin Gene-Related Peptide / genetics, metabolism* Cell Count Immunohistochemistry In Situ Hybridization Male RNA, Messenger / metabolism Rats Rats, Wistar Somatostatin / genetics, metabolism* Thyroid Gland / anatomy & histology, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 51110-01-1/Somatostatin; 83652-28-2/Calcitonin Gene-Related Peptide; 9007-12-9/Calcitonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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